Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges
| العنوان: | Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges |
|---|---|
| المؤلفون: | Hongpeng Jia, Honggang Cui, Enid Neptune |
| المصدر: | American Journal of Respiratory Cell and Molecular Biology |
| بيانات النشر: | American Thoracic Society, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Pulmonary and Respiratory Medicine, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Clinical Biochemistry, ACE2, Disease, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Viral entry, Pandemic, Humans, Medicine, Molecular Biology, License, therapy, Innate immune system, SARS-CoV-2, business.industry, COVID-19, Cell Biology, Creative commons, Immunity, Innate, COVID-19 Drug Treatment, 030104 developmental biology, 030228 respiratory system, Risk analysis (engineering), Spike Glycoprotein, Coronavirus, Angiotensin-Converting Enzyme 2, business, Perspectives |
| الوصف: | COVID-19 pandemic is sweeping the globe, even with the effective vaccine is on the horizon, new cases, and escalating mortality climbing every day. Angiotensin-converting enzyme 2 (ACE2) is the primary receptor for COVID-19 causative virus, SARS-CoV-2, and its complexation with spike proteins plays a crucial role in viral entry into host cells and the subsequent infection. Blocking this binding event, or reducing the accessibility of the virus to the ACE2 receptor, represents an alternative strategy to prevent COVID-19 disease. In addition, the biological significance of ACE2 in modulating the innate immune system and tissue repair cascades anchors its therapeutic potential for treating the infected patients. In this viewpoint article, we review the current efforts of exploiting ACE2 as a therapeutic target to address this dire medical need. We also provide a holistic view of the pros and cons of each treatment strategy. We highlight the fundamental and translational challenges in moving these research endeavors to clinical applications. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| تدمد: | 1535-4989 1044-1549 |
| DOI: | 10.1165/rcmb.2020-0322ps |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa1f7ccbd21770f9c8dfbfef6c2269b https://doi.org/10.1165/rcmb.2020-0322ps |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ffa1f7ccbd21770f9c8dfbfef6c2269b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15354989 10441549 |
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| DOI: | 10.1165/rcmb.2020-0322ps |