Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020
| العنوان: | Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020 |
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| المؤلفون: | Thorsten Fortwängler, Daniel Cadar, Frank Leypoldt, Martin Stangel, Dennis Rubbenstroth, Sabine Zange, Corinna Thomé-Bolduan, Philip Eisermann, Hendrik Wilking, Hans-Helmut Niller, Martin Beer, Jonas Schmidt-Chanasit, Kirsten Pörtner, Christina Frank, Andreas Osterman, Florian Hoffmann, Dennis Tappe, Petra Eggert, Klemens Angstwurm, Alexander Schlaphof |
| المصدر: | Emerging Infectious Diseases, Vol 27, Iss 5, Pp 1371-1379 (2021) Emerging Infectious Diseases |
| بيانات النشر: | Centers for Disease Control and Prevention, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | active case finding, variegated squirrel bornavirus 1, Infectious and parasitic diseases, RC109-216, Kidney, Serology, 0302 clinical medicine, Active Case Finding of Current Bornavirus Infections in Human Encephalitis Cases of Unknown Etiology, Germany, 2018–2020, Germany, Zoonoses, Epidemiology, 030212 general & internal medicine, infections, Prospective Studies, human encephalitis, Borna disease virus, BoDV-1, bornavirus, biology, bornavirus disease virus 1, Infectious Diseases, VSBV-1, Encephalitis, RNA, Viral, Medicine, epidemiology, meningitis/encephalitis, Microbiology (medical), medicine.medical_specialty, etiology, 030231 tropical medicine, ANIMAL EXPOSURE, Virus, 03 medical and health sciences, medicine, Animals, Humans, viruses, serologic analysis, business.industry, Research, biology.organism_classification, medicine.disease, Virology, Bornaviridae, Etiology, Case finding, business, case definition |
| الوصف: | Human bornavirus encephalitis is a severe and often fatal infection caused by variegated squirrel bornavirus 1 (VSBV-1) and Borna disease virus 1 (BoDV-1). We conducted a prospective study of bornavirus etiology of encephalitis cases in Germany during 2018-2020 by using a serologic testing scheme applied along proposed graded case definitions for VSBV-1, BoDV-1, and unspecified bornavirus encephalitis. Of 103 encephalitis cases of unknown etiology, 4 bornavirus infections were detected serologically. One chronic case was caused by VSBV-1 after occupational-related contact of a person with exotic squirrels, and 3 acute cases were caused by BoDV-1 in virus-endemic areas. All 4 case-patients died. Bornavirus etiology could be confirmed by molecular methods. Serologic testing for these cases was virus specific, discriminatory, and a practical diagnostic option for living patients if no brain tissue samples are available. This testing should be guided by clinical and epidemiologic suspicions, such as residence in virus-endemic areas and animal exposure. |
| اللغة: | English |
| تدمد: | 1080-6059 1080-6040 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff0ca08e2efc84de2d90a5289d747ad7 https://wwwnc.cdc.gov/eid/article/27/5/20-4490_article |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ff0ca08e2efc84de2d90a5289d747ad7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806059 10806040 |
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