Is Gas6 Protein Associated With Sticky Platelet Syndrome?
| العنوان: | Is Gas6 Protein Associated With Sticky Platelet Syndrome? |
|---|---|
| المؤلفون: | Pullmann R, Pavol Holly, Jan Stasko, Mária Škereňová, Lenka Bartosova, Peter Kubisz, Jela Ivankova |
| المصدر: | Clinical and Applied Thrombosis/Hemostasis. 16:701-704 |
| بيانات النشر: | SAGE Publications, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Platelet Aggregation, education, Arterial Occlusive Diseases, Thrombophilia, Polymorphism, Single Nucleotide, Pathogenesis, Internal medicine, Genotype, medicine, Humans, Genetic Predisposition to Disease, Platelet, Allele, business.industry, GAS6, Sticky platelet syndrome, Genetic Variation, Syndrome, Hematology, General Medicine, Middle Aged, medicine.disease, Thrombosis, Molecular biology, Endocrinology, Case-Control Studies, Intercellular Signaling Peptides and Proteins, Female, Blood Platelet Disorders, business |
| الوصف: | The aim of this study was to detect the prevalence of the polymorphisms of growth arrest—specific gene 6 (Gas6; Gas6 c. 834 + 7G > A) in patients with sticky platelet syndrome (SPS). Sticky platelet syndrome is a hereditary, autosomal dominant thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers—adenosine diphosphate (ADP) and epinephrine (EPI). The cause of SPS still remains unknown, but in recent years it was suggested that Gas6 protein may have a potential role in the pathogenesis of SPS. To assess the Gas6 polymorphisms (Gas6 c. 834 + 7G > A), 128 patients with SPS were included in the study and examined by polymerase chain reaction (PCR) method. GG genotype was detected in 63 (49.2%) patients, GA genotype in 53 (41.4%) patients, and AA genotype in 12 (9.4%) patients. The results in controls did not differ significantly compared to patients with SPS. Our findings did not prove allele A to be less associated with thrombosis and that ‘‘prothrombotic’’ allele G may be associated with higher risk of thrombosis. We cannot support the idea that Gas6 protein and Gas6 polymorphisms may be associated with thrombosis in SPS. |
| تدمد: | 1938-2723 1076-0296 |
| DOI: | 10.1177/1076029609345687 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff091569bf5303c4e58966de13dbb4f7 https://doi.org/10.1177/1076029609345687 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ff091569bf5303c4e58966de13dbb4f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19382723 10760296 |
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| DOI: | 10.1177/1076029609345687 |