Neutrophil Count on Admission Predicts Major In-hospital Events in Patients with a Non-ST-Segment Elevation Acute Coronary Syndrome
| العنوان: | Neutrophil Count on Admission Predicts Major In-hospital Events in Patients with a Non-ST-Segment Elevation Acute Coronary Syndrome |
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| المؤلفون: | Anastasios Kalofoutis, Spyridon Koulouris, Nikolaos Exadaktylos, Athanasios Kranidis, Ilias Karabinos, Socrates Pastromas |
| المصدر: | Clinical Cardiology. 32:561-568 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Acute coronary syndrome, Neutrophils, Clinical Investigations, Myocardial Infarction, Context (language use), Risk Assessment, Leukocyte Count, Patient Admission, Predictive Value of Tests, Recurrence, Risk Factors, Internal medicine, White blood cell, Troponin I, Odds Ratio, medicine, Humans, Hospital Mortality, Myocardial infarction, Acute Coronary Syndrome, Aged, Heart Failure, business.industry, Incidence, ST elevation, General Medicine, Odds ratio, Middle Aged, medicine.disease, Surgery, Logistic Models, Treatment Outcome, medicine.anatomical_structure, ROC Curve, Absolute neutrophil count, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers |
| الوصف: | BACKGROUND: Inflammation plays a key role in the pathogenesis of acute coronary syndromes (ACS). In this context we assessed neutrophil count as a predictor of major in‐hospital events in patients admitted for a non‐ST‐segment elevation (NSTE) ACS. METHODS: We measured neutrophils on admission in 160 patients with a NSTE ACS and we correlated their count with the incidence of a combined in‐hospital end point including: cardiac death, acute heart failure, ST‐segment elevation myocardial infarction, and recurrent myocardial ischemia. RESULTS: Patients who had a major in‐hospital event also had a higher neutrophil count (P = 0.02) and higher serum levels of troponin I (P = 0.04). In the univariate logistic regression analysis, in‐hospital major events could be predicted by troponin I > 0.07 ng/mL (odds ratio [OR]: 5.65, 95% confidence interval [CI]: 1.26–25.32, P = 0.02), white blood cell count > 8650 cells/µL (OR: 2.68, 95% CI: 1.03–6.95, P = 0.04), neutrophil count > 6700 cells/µL (OR: 7.74, 95% CI: 2.79–21.47, P < 0.001), and C‐reactive protein > 0.97 mg/dL (OR: 3.56, 95% CI: 1.13–11.19, P = 0.02). However, in multivariate regression, neutrophil count > 6700 cells/µL (OR: 6.52, 95% CI: 1.56–27.22, P = 0.01) was the only independent in‐hospital prognostic factor. CONCLUSIONS: In patients with a NSTE ACS of moderate or high risk, neutrophil count on admission may identify those who are at risk of having an adverse in‐hospital outcome. Copyright © 2009 Wiley Periodicals, Inc. |
| تدمد: | 1932-8737 0160-9289 |
| DOI: | 10.1002/clc.20624 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::febce5c5e13185b12f70f3bb61c63dc6 https://doi.org/10.1002/clc.20624 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....febce5c5e13185b12f70f3bb61c63dc6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19328737 01609289 |
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| DOI: | 10.1002/clc.20624 |