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A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria

التفاصيل البيبلوغرافية
العنوان: A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria
المؤلفون: V. Ndahindwa, Aline Uwimana, Daniel Ngamije, Umberto D'Alessandro, J. Curtis, Corine Karema, W. van Doren, C. Van Overmeir, Caterina I. Fanello
المصدر: Transactions of the Royal Society of Tropical Medicine and Hygiene. 102:412-420
بيانات النشر: Oxford University Press (OUP), 2008.
سنة النشر: 2008
مصطلحات موضوعية: Male, Artesunate, Rural Health, Dapsone, Pharmacology, chemistry.chemical_compound, Clinical trials, Malaria, Falciparum, Children, Antibacterial agent, education.field_of_study, biology, General Medicine, Protozoal diseases, Artemisinins, Treatment Outcome, Infectious Diseases, Proguanil, Child, Preschool, Sulfadoxine-pyrimethamine, Drug Therapy, Combination, Female, Safety, Chlorproguanil/dapsone, medicine.drug, medicine.medical_specialty, Efficacy, Genotype, Plasmodium falciparum, Population, Drug Administration Schedule, Antimalarials, Internal medicine, parasitic diseases, medicine, Animals, Humans, Africa, Central, education, Chlorproguanil, business.industry, Rwanda, Public Health, Environmental and Occupational Health, Amodiaquine, Infant, biology.organism_classification, Sulfadoxine/pyrimethamine, Malaria, Chlorproguanil/dapsone/artesunate, chemistry, Drug resistance, Artemisinin combination therapies (ACT), Parasitology, business
الوصف: We tested the efficacy and safety of chlorproguanil/dapsone co-administered with artesunate (CD+A) for the treatment of uncomplicated Plasmodium falciparum malaria in children compared with amodiaquine+sulfadoxine/pyrimethamine (AQ+SP) at two different sites in Rwanda. The trial was open label and 800 patients were randomly assigned to AQ+SP (n=400) or CD+A (n=400). Patients were hospitalised for 3 days and then followed-up weekly until Day 28 after treatment. Clinical and parasitological outcomes were recorded. Results showed that neither treatment was adequately efficacious. At one site, the adequate clinical and parasitological response (ACPR), PCR-adjusted, was 73.3% in the CD+A arm and 87.8% in the AQ+SP arm (P
تدمد: 0035-9203
DOI: 10.1016/j.trstmh.2008.01.013
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb6960327bf041f7f1d661495a6e579
https://doi.org/10.1016/j.trstmh.2008.01.013
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....feb6960327bf041f7f1d661495a6e579
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00359203
DOI:10.1016/j.trstmh.2008.01.013