Impact of prescription isodose level and collimator selection on dose homogeneity and plan quality in robotic radiosurgery
| العنوان: | Impact of prescription isodose level and collimator selection on dose homogeneity and plan quality in robotic radiosurgery |
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| المؤلفون: | Alexandra Hellerbach, Markus Eichner, Daniel Rueß, Klaus Luyken, Mauritius Hoevels, Michael Judge, Christian Baues, Maximilian Ruge, Martin Kocher, Harald Treuer |
| المصدر: | Strahlentherapie und Onkologie. 198:484-496 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Prescriptions, Robotic Surgical Procedures, Oncology, Radiotherapy Planning, Computer-Assisted, Humans, Radiotherapy Dosage, Radiology, Nuclear Medicine and imaging, Radiosurgery |
| الوصف: | Purpose In stereotactic radiosurgery (SRS), prescription isodoses and resulting dose homogeneities vary widely across different platforms and clinical entities. Our goal was to investigate the physical limitations of generating dose distributions with an intended level of homogeneity in robotic SRS. Methods Treatment plans for non-isocentric irradiation of 4 spherical phantom targets (volume 0.27–7.70 ml) and 4 clinical targets (volume 0.50–5.70 ml) were calculated using Sequential (phantom) or VOLOTM (clinical) optimizers (Accuray, Sunnyvale, CA, USA). Dose conformity, volume of 12 Gy isodose (V12Gy) as a measure for dose gradient, and treatment time were recorded for different prescribed isodose levels (PILs) and collimator settings. In addition, isocentric irradiation of phantom targets was examined, with dose homogeneity modified by using different collimator sizes. Results Dose conformity was generally high (nCI ≤ 1.25) and varied little with PIL. For all targets and collimator sets, V12Gy was highest for PIL ≥ 80% and lowest for PIL ≤ 65%. The impact of PIL on V12Gy was highest for isocentric irradiation and lowest for clinical targets (VOLOTM optimization). The variability of V12Gy as a function of collimator selection was significantly higher than that of PIL. V12Gy and treatment time were negatively correlated. Plans utilizing a single collimator with a diameter in the range of 70–80% of the target diameter were fastest, but showed the strongest dependence on PIL. Conclusion Inhomogeneous dose distributions with PIL ≤ 70% can be used to minimize dose to normal tissue. PIL ≥ 90% is associated with a marked and significant increase in off-target dose exposure. Careful selection of collimators during planning is even more important. |
| تدمد: | 1439-099X 0179-7158 |
| DOI: | 10.1007/s00066-021-01872-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feb3b5889fd33ac6ddefa15503b4c7cc https://doi.org/10.1007/s00066-021-01872-4 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....feb3b5889fd33ac6ddefa15503b4c7cc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1439099X 01797158 |
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| DOI: | 10.1007/s00066-021-01872-4 |