Tau‐positron emission tomography correlates with neuropathology findings
| العنوان: | Tau‐positron emission tomography correlates with neuropathology findings |
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| المؤلفون: | Bradley F. Boeve, Melissa E. Murray, Scott A. Przybelski, Dennis W. Dickson, David S. Knopman, Emily S. Lundt, David T.W. Jones, Jessica F. Tranovich, Christopher G. Schwarz, Matthew L. Senjem, Ronald C. Petersen, Val J. Lowe, Sabrina M. Albertson, Clifford R. Jack, Kejal Kantarci, Ping Fang, R. Ross Reichard, Fadi S. Hanna Al-Shaikh, Hoon Ki Min |
| المصدر: | Alzheimers Dement |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Epidemiology, tau Proteins, Autopsy, Standardized uptake value, Neuropathology, Hippocampal formation, Article, Temporal lobe, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Developmental Neuroscience, Alzheimer Disease, medicine, Humans, Aged, Aged, 80 and over, Hippocampal sclerosis, medicine.diagnostic_test, business.industry, Health Policy, Brain, medicine.disease, Psychiatry and Mental health, 030104 developmental biology, Positron emission tomography, Positron-Emission Tomography, Female, Neurology (clinical), Tauopathy, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery |
| الوصف: | Introduction Comparison of tau (flortaucipir) positron emission tomography (FTP-PET) to autopsy is important to demonstrate the relationship of FTP-PET to neuropathologic findings. Methods Autopsies were performed on 26 participants who had antemortem FTP-PET. FTP-PET standardized uptake value ratios (SUVRs) were compared to autopsy diagnoses and Braak tangle stage. Quantitative tau burden was compared to regional FTP-PET signal. Results Participants with Braak stages of IV or greater had elevated FTP-PET signal. FTP-PET was elevated in participants with Alzheimer's disease. An FTP-PET SUVR cut point of 1.29 was determined to be optimal. Quantitative measurements of hippocampal and temporal lobe tau burden were highly correlated to FTP-PET signal (rho's from 0.61 to 0.70, P ≤ .02). Discussion Elevated FTP-PET reflects Braak IV or greater neuropathology. Participants with primary age-related tauopathy and hippocampal sclerosis did not show elevated FTP-PET signal. Secondary neuropathologic diagnoses of Alzheimer's disease neuropathologic change can lead to borderline elevated FTP-PET signal. |
| تدمد: | 1552-5279 1552-5260 |
| DOI: | 10.1016/j.jalz.2019.09.079 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe31036f9f46a8e8f0ea9f2cd8fd555b https://doi.org/10.1016/j.jalz.2019.09.079 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fe31036f9f46a8e8f0ea9f2cd8fd555b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525279 15525260 |
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| DOI: | 10.1016/j.jalz.2019.09.079 |