Strategies in herbivory by mammals revisited: The role of liver metabolism in a juniper specialist ( Neotoma stephensi ) and a generalist ( Neotoma albigula )
| العنوان: | Strategies in herbivory by mammals revisited: The role of liver metabolism in a juniper specialist ( Neotoma stephensi ) and a generalist ( Neotoma albigula ) |
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| المؤلفون: | M. Denise Dearing, P. Ross Wilderman, Michele M. Skopec, James R. Halpert, Katharina Schramm, Teri J. Orr, Smiljka Kitanovic |
| المصدر: | Molecular Ecology. 29:1674-1683 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Herbivore, Neotoma albigula, biology, Cytochrome P450, Zoology, Metabolism, Generalist and specialist species, biology.organism_classification, Neotoma stephensi, 010603 evolutionary biology, 01 natural sciences, 03 medical and health sciences, 030104 developmental biology, Liver, Juniperus, Detoxification, Genetics, biology.protein, Animals, Herbivory, Sigmodontinae, Juniper, Ecology, Evolution, Behavior and Systematics |
| الوصف: | Although herbivory is widespread among mammals, few species have adopted a strategy of dietary specialization. Feeding on a single plant species often exposes herbivores to high doses of plant secondary metabolites (PSMs), which may exceed the animal's detoxification capacities. Theory predicts that specialists will have unique detoxification mechanisms to process high levels of dietary toxins. To evaluate this hypothesis, we compared liver microsomal metabolism of a juniper specialist, Neotoma stephensi (diet >85% juniper), to a generalist, N. albigula (diet ≤30% juniper). Specifically, we quantified the concentration of a key detoxification enzyme, cytochrome P450 2B (CYP2B) in liver microsomes, and the metabolism of α-pinene, the most abundant terpene in the juniper species consumed by the specialist woodrat. In both species, a 30% juniper diet increased the total CYP2B concentration (2-3×) in microsomes and microsomal α-pinene metabolism rates (4-fold). In N. stephensi, higher levels of dietary juniper (60% and 100%) further induced CYP2B and increased metabolism rates of α-pinene. Although no species-specific differences in metabolism rates were observed at 30% dietary juniper, total microsomal CYP2B concentration was 1.7× higher in N. stephensi than in N. albigula (p |
| تدمد: | 1365-294X 0962-1083 |
| DOI: | 10.1111/mec.15431 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc7df6eda09a8c33e0ff4362c99d4a3 https://doi.org/10.1111/mec.15431 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fdc7df6eda09a8c33e0ff4362c99d4a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1365294X 09621083 |
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| DOI: | 10.1111/mec.15431 |