Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor–κB Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors
| العنوان: | Glycyrrhizin Inhibits Interleukin-8 Production and Nuclear Factor–κB Activity in Lung Epithelial Cells, but Not Through Glucocorticoid Receptors |
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| المؤلفون: | Yuichiro Baba, Hiroshi Katsuki, Takeshi Miyata, Kazumi Yokomizo, Yoichiro Isohama, Hironori Takei, Akinori Hisatsune |
| المصدر: | Journal of Pharmacological Sciences Journal of Pharmacological Sciences, Vol 106, Iss 3, Pp 460-468 (2008) |
| بيانات النشر: | Japanese Pharmacological Society, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | glycyrrhizin, Active Transport, Cell Nucleus, Anti-Inflammatory Agents, A549 cell, Biology, Article, Transactivation, chemistry.chemical_compound, Receptors, Glucocorticoid, Glucocorticoid receptor, Cell Line, Tumor, interleukin (IL)-8, Humans, Interleukin 8, Promoter Regions, Genetic, Receptor, Glycyrrhizin, Lung, Pharmacology, lcsh:RM1-950, Interleukin-8, Transcription Factor RelA, Interleukin, Epithelial Cells, DNA, Glycyrrhizic Acid, Molecular biology, lcsh:Therapeutics. Pharmacology, chemistry, Molecular Medicine, glucocorticoid, Tumor necrosis factor alpha, hormones, hormone substitutes, and hormone antagonists, nuclear factor (NF)-κ B |
| الوصف: | This study was designed to examine the glucocorticoid-like inhibitory effect of glycyrrhizin (GL) on interleukin (IL)-8 production in A549 lung epithelial cells. GL, as well as dexamethasone (DEX) inhibited both tumor necrosis factor (TNF)-α –and IL-1β –induced IL-8 production, mRNA expression, and promoter activity in A549 cells. Both GL and DEX inhibited transactivation of nuclear factor (NF)-κ B, without inhibiting translocation of the NF-κ B p65 subunit to the nucleus. However, the effect of GL was insensitive to RU486, a GR antagonist, and to GR knockdown by siRNA. Furthermore, only GL inhibited DNA binding of p65 to the IL-8 promoter region. These findings indicated that GL had a glucocorticoid-like inhibitory effect on IL-8 production via a mechanism that differs from that of glucocorticoids. Keywords:: glycyrrhizin, glucocorticoid, nuclear factor (NF)-κ B, interleukin (IL)-8, A549 cell |
| تدمد: | 1347-8648 1347-8613 |
| DOI: | 10.1254/jphs.fp0072378 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb65469f5137585c3e061db494d2a18 https://doi.org/10.1254/jphs.fp0072378 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fdb65469f5137585c3e061db494d2a18 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13478648 13478613 |
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| DOI: | 10.1254/jphs.fp0072378 |