Effects of different therapeutic modalities for postacne scars on circulating collagen III
| العنوان: | Effects of different therapeutic modalities for postacne scars on circulating collagen III |
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| المؤلفون: | Mohamed Makboul, Amira A Abdel Motaleb, Sahar A. Ismail, Emad A. Taha, Ensaf M Abdel-Magiud, Sohair K. Sayed, Suzan Kamel-ElSayed, Radwa M Bakr |
| المصدر: | Journal of Cosmetic Dermatology. 19:1517-1521 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, Caustics, Urology, Scars, Dermatology, Severity of Illness Index, Cicatrix, Young Adult, 030207 dermatology & venereal diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Acne Vulgaris, Photography, Humans, Medicine, In patient, Trichloroacetic Acid, Trichloroacetic acid, Skin, biology, business.industry, Collagen iii, Hypertrophy, Therapeutic modalities, Collagen Type III, Treatment Outcome, chemistry, Quartile, Case-Control Studies, 030220 oncology & carcinogenesis, Dry Needling, biology.protein, Biomarker (medicine), Female, medicine.symptom, business, Elastin, Biomarkers |
| الوصف: | BACKGROUND Therapies for postacne scarring act through modulation of elastin and collagen, and collagen III might therefore represent a biomarker of treatment effectiveness. PATIENTS AND METHODS Patients (n = 70) with postacne scars and individuals without scars (n = 56) were included in this case-control study. Patients were treated with Dermaroller microneedling, trichloroacetic acid chemical reconstruction, punch excision, or scar subcision. Scar severity was graded immediately before and after treatment with a photographic quartile scale and the ECCA scale. Serum levels of collagen III were measured in control individuals and in patients, before treatment, 1 month after the first treatment session, and 4 months after the final session. RESULTS Circulating levels of collagen III were significantly higher in patients with postacne scarring (24.1 ± 12.5) before treatment than in control individuals (2.6 ± 0.8). Circulating levels of collagen in patients were significantly lower 4 months posttreatment (14.3 ± 8.1) than at baseline. The mean percentage change in serum collagen III was positively correlated with both the mean percentage improvement by photographic evaluation (r = .530, P |
| تدمد: | 1473-2165 1473-2130 |
| DOI: | 10.1111/jocd.13184 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd931b55d3adac26a374e8cda392f25c https://doi.org/10.1111/jocd.13184 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....fd931b55d3adac26a374e8cda392f25c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732165 14732130 |
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| DOI: | 10.1111/jocd.13184 |