A novel in vitro pharmacokinetic/pharmacodynamic model based on two-compartment open model used to simulate serum drug concentration-time profiles
| العنوان: | A novel in vitro pharmacokinetic/pharmacodynamic model based on two-compartment open model used to simulate serum drug concentration-time profiles |
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| المؤلفون: | Yuko Ohara-Nemoto, Tsutomu Tomita, Yoshifumi Takeda, Hitomi Moriyama, Ken Kikuchi, Ayako Ozawa |
| المصدر: | Microbiology and immunology. 51(5):567-575 |
| بيانات النشر: | Center for Academic Publications Japan, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Staphylococcus aureus, Intravenous infusion, Immunology, Cefazolin, Microbial Sensitivity Tests, Pharmacology, Fosfomycin, Escherichia coli O157, Microbiology, Models, Biological, chemistry.chemical_compound, Pharmacokinetics, Virology, Two-compartment model, Medicine, Humans, Infusions, Intravenous, Escherichia coli Infections, Pharmacodynamic model, business.industry, Washout, Body Fluid Compartments, Staphylococcal Infections, Anti-Bacterial Agents, Regimen, chemistry, Pharmaceutical Preparations, Pharmacodynamics, Agarose, business, Perfusion, H7, medicine.drug |
| الوصف: | An in vitro pharmacokinetic/pharmacodynamic perfusion model that simulates a two-compartment open model of serum drug concentration-time profiles following intravenous bolus injection and infusion was developed and mathematically described. In the present apparatus model, flow was kept in a one-way mode to avoid liquid traffic, and the washout effect seen in dilution models was overcome by embedding the tested bacteria in low melting point agarose gel. The validity of the equations and the reproducibility of the apparatus model were ascertained by simulating the concentration-time profiles of cefazolin and fosfomycin by substitution of their pharmacokinetic parameters obtained from humans for the equations. An empirical regimen 1X(q24h) of 1 g with cefazolin administered by intravenous infusion effectively killed a Staphylococcus aureus strain. The same regimen with fosfomycin produced a marked kill-curve with a fosfomycin-susceptible enterohaemorrhagic Escherichia coli O157:H7, whereas considerable regrowth was observed with a resistant strain. These results indicated that the present model was able to provide a convenient and reliable method for evaluating the efficacy of antimicrobial agents administered by intravenous infusion. Microbiology and immunology. 51(5), pp.567-575; 2007 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0385-5600 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd85831c4fc4bad455f2f3dcc934a286 http://hdl.handle.net/10069/20165 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd85831c4fc4bad455f2f3dcc934a286 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03855600 |
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