Effects of a high-calcium diet on serum insulin-like growth factor-1 levels in magnesium-deficient rats
| العنوان: | Effects of a high-calcium diet on serum insulin-like growth factor-1 levels in magnesium-deficient rats |
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| المؤلفون: | Yasutaka Kajita, Misao Miwa, Hiroshi Matsuzaki |
| المصدر: | Magnesium Research. 25:126-130 |
| بيانات النشر: | John Libbey Eurotext, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, medicine.medical_treatment, Clinical Biochemistry, Serum insulin, chemistry.chemical_element, Biochemistry, Internal medicine, Male rats, medicine, Animals, Magnesium, Bone formation, Insulin-Like Growth Factor I, Rats, Wistar, Molecular Biology, Calcium diet, Calcium metabolism, biology, Chemistry, Growth factor, Diet, Rats, Endocrinology, Osteocalcin, biology.protein, Calcium, Magnesium Deficiency |
| الوصف: | In order to clarify the effects of a high-calcium (Ca) diet on bone formation in magnesium (Mg)-deficient rats, this study focused on the effects of a high-Ca diet on serum insulin-like growth factor-1 (IGF-1) levels. Male rats were randomized by weight into four groups, and fed one of four experimental diets containing two different Mg concentrations (0.05% (normal-Mg) or Mg-free (Mg-deficient)), and two different Ca concentrations (0.5% (normal-Ca) or 1.0% (high-Ca)) for 14 days. Serum concentrations of osteocalcin and IGF-1 were significantly lower in rats fed the Mg-deficient diet than in rats fed the normal-Mg diet. On the other hand, dietary Ca concentration had no significant influence on serum concentrations of osteocalcin and IGF-1. This study suggested that: 1) a high-Ca diet has no preventive effects on the decreased bone formation seen in Mg-deficient rats; and 2) a high-Ca diet does not enhance serum IGF-1 levels in Mg-deficient rats. Moreover, unchanged serum IGF-1 concentrations may contribute to the decreased bone formation seen in Mg-deficient rats receiving a high-Ca diet. |
| تدمد: | 1952-4021 0953-1424 |
| DOI: | 10.1684/mrh.2012.0320 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd41f8137bd03008be30666c520da629 https://doi.org/10.1684/mrh.2012.0320 |
| رقم الانضمام: | edsair.doi.dedup.....fd41f8137bd03008be30666c520da629 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19524021 09531424 |
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| DOI: | 10.1684/mrh.2012.0320 |