Extremely premature infants born at 23–25 weeks gestation are at substantial risk for pulmonary hypertension
| العنوان: | Extremely premature infants born at 23–25 weeks gestation are at substantial risk for pulmonary hypertension |
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| المؤلفون: | Hannes Sallmon, Martin Koestenberger, Alexander Avian, Friedrich Reiterer, Bernhard Schwaberger, Katharina Meinel, Gerhard Cvirn, Stefan Kurath-Koller, Andreas Gamillscheg, Georg Hansmann |
| المصدر: | Journal of Perinatology. 42:781-787 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Hypertension, Pulmonary, Infant, Newborn, Infant, Obstetrics and Gynecology, Gestational Age, Sildenafil Citrate, Young Adult, Pregnancy, Infant, Extremely Premature, Pediatrics, Perinatology and Child Health, Humans, Female, Prospective Studies, Child, Biomarkers, Bronchopulmonary Dysplasia |
| الوصف: | Objective Extremely low gestational age newborns (ELGANs) represent an especially vulnerable population. Herein, we aimed to determine incidence and severity of pulmonary hypertension associated with bronchopulmonary dysplasia (BPD-PH) in extremely immature ELGANs (gestational age: 230/6–256/7 weeks). Methods In this prospective observational cohort study, we assessed BPD-PH by means of several echocardiography markers and serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels at 3 and 12 months of chronological age. In addition, we analyzed incidence and efficacy of pharmacologic treatment for BPD-PH. Results At 3 months 15/34 ELGANs had echocardiographic evidence of BPD-PH, while at 12 months of age 6/34 still had PH. PH-targeted therapy consisted of sildenafil monotherapy in 11 and dual oral combination therapy (sildenafil and macitentan) in four ELGANs at 3 and 12 months. Conclusion 44% (15/34) of ELGANs developed BPD-PH. All received PH-targeted pharmacotherapy at 3 months, leading to hemodynamic improvements at 12 months in most infants. |
| تدمد: | 1476-5543 0743-8346 |
| DOI: | 10.1038/s41372-022-01374-w |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1b19011dbbc044010777f9a528cb71 https://doi.org/10.1038/s41372-022-01374-w |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd1b19011dbbc044010777f9a528cb71 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765543 07438346 |
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| DOI: | 10.1038/s41372-022-01374-w |