A population-based study of pediatric anaplastic large cell lymphoma
| العنوان: | A population-based study of pediatric anaplastic large cell lymphoma |
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| المؤلفون: | Sheila Pritchard, Bonnie G. Massing, Angela J. Alessandri, Kirk R. Schultz |
| المصدر: | Cancer. 94:1830-1835 |
| بيانات النشر: | Wiley, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, Cancer Research, Pediatrics, medicine.medical_specialty, Pathology, Adolescent, CD30, Population, Ethnic origin, Southeast asian, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Epidemiology, Ethnicity, Humans, Medicine, Child, education, Anaplastic large-cell lymphoma, Demography, education.field_of_study, British Columbia, business.industry, Incidence, Incidence (epidemiology), Infant, Newborn, Infant, Prognosis, medicine.disease, Immunohistochemistry, Epidemiologic Studies, Treatment Outcome, Oncology, El Niño, Child, Preschool, Female, Lymphoma, Large B-Cell, Diffuse, business |
| الوصف: | BACKGROUND Anaplastic large cell lymphoma (ALCL) is a relatively rare form of non-Hodgkin lymphoma (NHL) in children constituting 10–15% of this entity. To the authors' knowledge, there are no population-based pediatric studies in the literature, and incidence estimates have not been attempted. METHODS A population-based study of all children in British Columbia, Canada, younger than 15 years of age presenting between January 1988 and December 1999 with an immunohistologically confirmed diagnosis of CD30+ ALCL was completed. Demographic, ethnic, clinical, treatment, and outcome details were collected on all patients. Population figures were obtained from census data through the BC STATS. RESULTS Ten patients were identified and confirmed to have ALCL on the basis of morphology and immunohistochemical stains. This equates to an annual incidence of 1.2 per million children younger than 15 years of age. The mean age at diagnosis was 8.23 years with a range of 1.4–13.0 years. There was an overrepresentation of East and Southeast Asian patients (40%) in the ALCL group compared with other subtypes of NHL and the pediatric population of British Columbia. Twenty percent of the patients had evidence of central nervous system (CNS) disease at diagnosis. CONCLUSIONS The annual incidence of ALCL in children younger than 15 years of age in British Columbia is 1.2 per million. The overrepresentation of East and Southeast Asian ethnic origin remains unexplained. The rate of CNS involvement is much higher than that previously reported in large non-population-based series (0–3%). Although the low numbers do not allow firm conclusions, it would seem prudent to continue to investigate all newly diagnosed patients for CNS involvement in British Columbia. Cancer 2002;94:1830–5. © 2002 American Cancer Society. DOI 10.1002/cncr.10396 |
| تدمد: | 1097-0142 0008-543X |
| DOI: | 10.1002/cncr.10396 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf3967f0e71935cd0072d2a3c56c595 https://doi.org/10.1002/cncr.10396 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fcf3967f0e71935cd0072d2a3c56c595 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
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| DOI: | 10.1002/cncr.10396 |