Development of refractive errors - what can we learn from inherited retinal dystrophies?
| العنوان: | Development of refractive errors - what can we learn from inherited retinal dystrophies? |
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| المؤلفون: | Laurence H M Pierrache, Reinier O. Schlingemann, Jan Willem R. Pott, Clasien J. Oomen, Jan Roelof Polling, Michelle Hendriks, Hester Y. Kroes, Wendy A. G. van Zelst-Stams, Albert Hofman, Frans P.M. Cremers, Mary J. van Schooneveld, Redmer van Leeuwen, Ramon A. C. van Huet, F. Nienke Boonstra, Mies M. van Genderen, Caroline C W Klaver, Carel B. Hoyng, Maarten Kamermans, Camiel J. F. Boon, Magda A. Meester-Smoor, L. Ingeborgh van den Born, Nathalie M. Bax, Stanley Lambertus, Virginie J. M. Verhoeven, Yvonne de Jong-Hesse, Arthur A.B. Bergen, J Schuil, Astrid S. Plomp, Gabriëlle H.S. Buitendijk, B Jeroen Klevering |
| المساهمون: | Erasmus MC other, Epidemiology, Ophthalmology, Netherlands Institute for Neuroscience (NIN), Biomedical Engineering and Physics, ANS - Cellular & Molecular Mechanisms, Human Genetics, ACS - Amsterdam Cardiovascular Sciences, ARD - Amsterdam Reproduction and Development, ACS - Atherosclerosis & ischemic syndromes |
| المصدر: | American Journal of Ophthalmology, 182, 81-89. Elsevier Inc. Hendriks, M, Verhoeven, V J M, Buitendijk, G H S, Polling, J R, Meester-Smoor, M A, Hofman, A, Kamermans, M, Ingeborgh van den Born, L, Klaver, C C W & RD5000 Consortium 2017, ' Development of Refractive Errors—What Can We Learn From Inherited Retinal Dystrophies? ', American Journal of Ophthalmology, vol. 182, pp. 81-89 . https://doi.org/10.1016/j.ajo.2017.07.008 American Journal of Ophthalmology, 182, 81-89 American Journal of Ophthalmology, 182, 81-89. Elsevier USA American Journal of Ophthalmology, 182, pp. 81-89 American Journal of Ophthalmology, 182, 81. Elsevier USA American Journal of Ophthalmology American journal of ophthalmology, 182, 81-89. Elsevier USA |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Refractive error, genetic structures, DNA Mutational Analysis, Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12], chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Myopia, Medicine, Dioptre, education.field_of_study, Eye Diseases, Hereditary, Middle Aged, 3. Good health, medicine.anatomical_structure, Hyperopia, Population study, Female, Retinal Dystrophies, Adult, medicine.medical_specialty, Retinal Bipolar Cells, Calcium Channels, L-Type, Population, 03 medical and health sciences, Ophthalmology, Journal Article, Humans, Retinal Photoreceptor Cell Inner Segment, education, Eye Proteins, Retinal pigment epithelium, business.industry, Calcium-Binding Proteins, Retinal, Odds ratio, medicine.disease, Retinal Photoreceptor Cell Outer Segment, eye diseases, 030104 developmental biology, chemistry, Case-Control Studies, Mutation, Synapses, 030221 ophthalmology & optometry, sense organs, business |
| الوصف: | PURPOSE: It is unknown which retinal cells are involved in the retina-to-sclera signaling cascade causing myopia. As inherited retinal dystrophies (IRD) are characterized by dysfunction of a single retinal cell type and have a high risk of refractive errors, a study investigating the affected cell type, causal gene, and refractive error in IRDs may provide insight herein. DESIGN: Case-control study. METHODS: STUDY POPULATION: Total of 302 patients with IRD. from 2 ophthalmogenetic centers in the Netherlands. REFERENCE POPULATION: Population-based Rotterdam Study-III and Erasmus Rucphen Family Study (N = 5550). Distributions and mean spherical equivalent (SE) were calculated for main affected cell type and causal gene; and risks of myopia and hyperopia were evaluated using logistic regression. RESULTS: Bipolar cell-related dystrophies were associated with the highest risk of SE high myopia 239.7; odds ratio (OR) mild hyperopia 263.2, both P |
| وصف الملف: | image/pdf |
| اللغة: | English |
| تدمد: | 0002-9394 |
| DOI: | 10.1016/j.ajo.2017.07.008 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcea991019b6ecc07882ea584a3c484a https://doi.org/10.1016/j.ajo.2017.07.008 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fcea991019b6ecc07882ea584a3c484a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00029394 |
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| DOI: | 10.1016/j.ajo.2017.07.008 |