Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance
| العنوان: | Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance |
|---|---|
| المؤلفون: | Shail K. Sharma, Werner A. Klee, Marshall W. Nirenberg |
| المصدر: | Proceedings of the National Academy of Sciences. 72:3092-3096 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 1975. |
| سنة النشر: | 1975 |
| مصطلحات موضوعية: | medicine.medical_specialty, Adenosine, Substance-Related Disorders, Adenylate kinase, (+)-Naloxone, Hybrid Cells, Pharmacology, Inhibitory postsynaptic potential, Models, Biological, Cyclase, Drug tolerance, Internal medicine, medicine, Humans, Receptor, Multidisciplinary, Morphine, biology, Naloxone, Chemistry, Prostaglandins E, Drug Tolerance, Enzyme assay, Endocrinology, biology.protein, Cell Division, Research Article, Adenylyl Cyclases, medicine.drug |
| الوصف: | Narcotics affect adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in two opposing ways, both mediated by the opiate receptor. The first process is the readily reversible inhibition of the enzyme by narcotics; the second is a compensatory increase in enzyme activity which is delayed in onset and relatively stable. Late positive regulation of the enzyme counteracts the inhibitory influence of morphine and is responsible for narcotic dependence and tolerance. The coupled inhibitory and positive regulatory mechanisms for adenylate cyclase provide a means of activating and deactivating neural circuits hours after the initial event and thus may play a role in a memory process. |
| تدمد: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.72.8.3092 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbbadbe687ec258634fd080feb297ee https://doi.org/10.1073/pnas.72.8.3092 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fcbbadbe687ec258634fd080feb297ee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
|---|---|
| DOI: | 10.1073/pnas.72.8.3092 |