Ginsenosides Rg5 and Rk1 Enriched Cultured Wild Ginseng Root Extract Bioconversion of Pediococcus pentosaceus HLJG0702: Effect on Scopolamine-Induced Memory Dysfunction in Mice
| العنوان: | Ginsenosides Rg5 and Rk1 Enriched Cultured Wild Ginseng Root Extract Bioconversion of Pediococcus pentosaceus HLJG0702: Effect on Scopolamine-Induced Memory Dysfunction in Mice |
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| المؤلفون: | So Min Lee, Jee Eun Choi, Yong Yeon, Jae Geun Lee, Su Jin Kang, Chul Joong Kim, Ye ji Lee, Hyeon Yeol Ryu, Yu Ri Kim, Kyung Seuk Song, Yeo Ok Choi, Kyu Sup An, Byeong Ju Kang |
| المصدر: | Nutrients, Vol 11, Iss 5, p 1120 (2019) Nutrients Volume 11 Issue 5 |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Ginsenosides, Scopolamine, Morris water navigation task, Panax, lcsh:TX341-641, Pharmacology, GPI-Linked Proteins, Plant Roots, Article, Pediococcus pentosaceus, 03 medical and health sciences, Ginseng, chemistry.chemical_compound, Tissue culture, 0302 clinical medicine, Memory, cultured wild ginseng root, Memory improvement, medicine, Avoidance Learning, Animals, Maze Learning, chemistry.chemical_classification, Memory Disorders, Nutrition and Dietetics, Behavior, Animal, Plant Extracts, Brain, food and beverages, acetylcholinesterase, Acetylcholinesterase, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Enzyme, chemistry, Ginsenoside, Fermentation, Cholinesterase Inhibitors, memory deficit, lcsh:Nutrition. Foods and food supply, 030217 neurology & neurosurgery, Acetylcholine, ginsenoside Rg5/Rk1, Food Science, medicine.drug |
| الوصف: | Wild ginseng is known to contain additional physiologically and pharmacologically active substances than common ginseng. The utilization of this herb can be maximized by altering its composition via tissue culture generating adventitious roots. We enriched the content of specific ginsenosides and investigated their role in ameliorating memory impairment. Cultured wild ginseng root was subjected to extraction, steaming, and fermentation using Pediococcus pentosaceus HLJG0702 to enhance the levels of ginsenosides Rg5 /Rk1. The analysis of product, HLJG0701, confirmed target ginsenosides. We analyzed the inhibitory effect of ginsenoside Rg5/Rk1, HLJG0701 and the raw material on acetylcholinesterase. Further, we performed Morris water maze, Y-maze, and passive avoidance tasks with mice exhibiting memory deficit induced by scopolamine, and we analyzed the concentrations of acetylcholinesterase and acetylcholine in their brains. Studies showed that the levels of ginsenosides Rg5 /Rk1, not found in the raw material, were enhanced in HLJG0701. Ginsenosides and HLJG0701 significantly inhibited acetylcholinesterase unlike the raw material. In all behavioral tasks, HLJG0701 showed memory improvement. It reduced acetylcholinesterase, whereas, it preserved acetylcholine in brain. In conclusion, cultured wild ginseng root extract fermented by P. pentosaceus HLJG0702 contains the distinctive ginsenosides Rg5/Rk1, which may ameliorate memory impairment via inhibition of acetylcholinesterase resulting in increased acetylcholine levels in the brain. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5fa709dd4dead7283eb43437cf51c4 https://www.mdpi.com/2072-6643/11/5/1120 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fc5fa709dd4dead7283eb43437cf51c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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