التفاصيل البيبلوغرافية
| العنوان: |
TERRA: telomeric repeat-containing RNA |
| المؤلفون: |
Joachim Lingner, Brian Luke |
| المصدر: |
The EMBO Journal; Vol 28
The EMBO Journal |
| بيانات النشر: |
Nature Publishing Group, 2009. |
| سنة النشر: |
2009 |
| مصطلحات موضوعية: |
DNA Replication, Telomerase, Telomeric repeat-containing RNAs, RNA, Untranslated, Heterochromatin, Chromosome Ends, non-coding RNA, Telomeric heterochromatin, Biology, telomerase, Models, Biological, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Messenger-Rna, Transcription (biology), Hnrnp A1, Saccharomyces-Cerevisiae, Animals, Humans, Molecular Biology, 030304 developmental biology, Repetitive Sequences, Nucleic Acid, Genetics, 0303 health sciences, General Immunology and Microbiology, General Neuroscience, TERRA, Telomere, Non-coding RNA, telomeres, Chromatin Assembly and Disassembly, Mammalian Telomeres, Human-Cells, Yeast, Chromatin, 030220 oncology & carcinogenesis, Focus Review, chromatin, Human Fibroblasts, Transcription, X-Chromosome |
| الوصف: |
Telomeres, the physical ends of eukaryotic chromosomes, consist of tandem arrays of short DNA repeats and a large set of specialized proteins. A recent analysis has identified telomeric repeat-containing RNA ( TERRA), a large non-coding RNA in animals and fungi, which forms an integral component of telomeric heterochromatin. TERRA transcription occurs at most or all chromosome ends and it is regulated by RNA surveillance factors and in response to changes in telomere length. TERRA functions that are emerging suggest important roles in the regulation of telomerase and in orchestrating chromatin remodelling throughout development and cellular differentiation. The accumulation of TERRA at telomeres can also interfere with telomere replication, leading to a sudden loss of telomere tracts. Such a phenotype can be observed upon impairment of the RNA surveillance machinery or in cells from ICF (Immunodeficiency, Centromeric region instability, Facial anomalies) patients, in which TERRA is upregulated because of DNA methylation defects in the subtelomeric region. Thus, TERRA may mediate several crucial functions at the telomeres, a region of the genome that had been considered to be transcriptionally silent. The EMBO Journal (2009) 28, 2503-2510. doi: 10.1038/emboj.2009.166; Published online 23 July 2009 Subject Categories: chromatin & transcription; RNA |
| اللغة: |
English |
| تدمد: |
1460-2075 |
| DOI: |
10.1038/emboj.2009.166 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0770631134b285375601f5bd5a7749 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....fc0770631134b285375601f5bd5a7749 |
| قاعدة البيانات: |
OpenAIRE |