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Granulocyte colony-stimulating factor in the treatment of high-risk febrile neutropenia: A multicenter randomized trial

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العنوان: Granulocyte colony-stimulating factor in the treatment of high-risk febrile neutropenia: A multicenter randomized trial
المؤلفون: Luis Paz-Ares, Antonio Rueda, Carlos Lage Gómez, Carlos Lumbreras, Jose Luis Perez-Gracia, Hernán Cortés-Funes, A. Yubero, María Victoria Tornamira, Marta López-Brea, Alberto Arcediano, Rocio Garcia-Carbonero, Vicente Guillem, Alejandro Tres, Javier Hornedo, Fernando Ribera, Jose I. Mayordomo
المساهمون: [García-Carbonero,R, Tornamira,MV, Arcediano,A, Gómez,C, Pérez-Gracia,JL, Hornedo,J, Cortés-Funes,H, Paz-Ares,L] Division of Medical Oncology, Hospital Universitario Doce de Octubre, Madrid, Spain. [Mayordomo,JI, Yubero,A, Trés,A] Division of Medical Oncology, Hospital Clínico, Zaragoza, Spain. [López-Brea,M, Rivera,F] Division of Medical Oncology, Hospital M. Valdecilla, Santander, Spain. [Rueda Domínguez,A] Division of Medical Oncology, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Guillém,V] Division of Medical Oncology, Instituto Valenciano de Oncologia, Valencia, Spain. [Lumbreras,C] Division of Infectious Diseases, Hospital Universitario Doce de Octubre, Madrid, Spain.
المصدر: Scopus-Elsevier
مصطلحات موضوعية: Male, Cancer Research, Time Factors, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Models [Medical Subject Headings], Phenomena and Processes::Physical Phenomena::Time::Time Factors [Medical Subject Headings], Cost-Benefit Analysis, España, Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Hematopoietic Cell Growth Factors::Colony-Stimulating Factors::Granulocyte Colony-Stimulating Factor [Medical Subject Headings], Named Groups::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Temperature Changes::Fever [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Granulocyte Colony-Stimulating Factor, Medicine, Prospective Studies, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Clinical Protocols::Antineoplastic Protocols::Antineoplastic Combined Chemotherapy Protocols [Medical Subject Headings], Geographicals::Geographic Locations::Europe::Spain [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Schedule [Medical Subject Headings], Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Health Care Evaluation Mechanisms::Statistics as Topic::Survival Analysis [Medical Subject Headings], Leukopenia, Diseases::Neoplasms [Medical Subject Headings], Middle Aged, Chemotherapy regimen, Neoplasias, Granulocyte colony-stimulating factor, Anti-Bacterial Agents, Treatment Outcome, Antibacterianos, Oncology, Amikacin, Absolute neutrophil count, Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Leukocyte Disorders::Leukopenia::Agranulocytosis::Neutropenia [Medical Subject Headings], Female, medicine.symptom, Análisis Costo-Beneficio, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [Medical Subject Headings], medicine.drug, Protocolos de Quimioterapia Combinada Antineoplásica, medicine.medical_specialty, Neutropenia, Fever, Análisis de Supervivencia, Resultado del Tratamiento, Check Tags::Male [Medical Subject Headings], Drug Administration Schedule, Health Care::Health Care Economics and Organizations::Economics::Costs and Cost Analysis::Cost-Benefit Analysis [Medical Subject Headings], Internal medicine, Humans, Health Care::Health Care Facilities, Manpower, and Services::Health Services::Patient Care::Hospitalization::Length of Stay [Medical Subject Headings], Named Groups::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Aged, Proportional Hazards Models, Performance status, business.industry, Esquema de Medicación, Length of Stay, medicine.disease, Survival Analysis, Surgery, Factor Estimulante de Colonias de Granulocitos, Check Tags::Female [Medical Subject Headings], Spain, Health Care::Health Services Administration::Quality of Health Care::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care)::Treatment Outcome [Medical Subject Headings], Modelos de Riesgos Proporcionales, business, Fiebre, Factores de Tiempo, Febrile neutropenia, Tiempo de Internación
الوصف: Presented in part at the 35th American Society of Clinical Oncology meeting. Atlanta (GA); 1999. Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; BACKGROUND Granulocyte colony-stimulating factors (G-CSFs) have been shown to help prevent febrile neutropenia in certain subgroups of cancer patients undergoing chemotherapy, but their role in treating febrile neutropenia is controversial. The purpose of our study was to evaluate-in a prospective multicenter randomized clinical trial-the efficacy of adding G-CSF to broad-spectrum antibiotic treatment of patients with solid tumors and high-risk febrile neutropenia. METHODS A total of 210 patients with solid tumors treated with conventional-dose chemotherapy who presented with fever and grade IV neutropenia were considered to be eligible for the trial. They met at least one of the following high-risk criteria: profound neutropenia (absolute neutrophil count
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe6e8098b0d7b1788f3f6b5647ab97d
http://www.scopus.com/inward/record.url?eid=2-s2.0-0035798795&partnerID=MN8TOARS
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....fbe6e8098b0d7b1788f3f6b5647ab97d
قاعدة البيانات: OpenAIRE
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