Paternal age and psychiatric disorders: findings from a Dutch population registry
| العنوان: | Paternal age and psychiatric disorders: findings from a Dutch population registry |
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| المؤلفون: | Maartje F. Aukes, Wijnand Laan, Eric A. M. Hennekam, Roel A. Ophoff, Jacobine E. Buizer-Voskamp, René S. Kahn, Fabian Termorshuizen, Wouter G. Staal, Marco P. Boks |
| المصدر: | Schizophrenia Research, 129, 2-3, pp. 128-32 Schizophrenia Research, 129, 128-32 |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Bipolar Disorder, behavioral disciplines and activities, Paternal Age, Article, Young Adult, mental disorders, medicine, Humans, Registries, Bipolar disorder, Young adult, Child, Psychiatry, Biological Psychiatry, Netherlands, Retrospective Studies, Depressive Disorder, Major, Mental Health [NCEBP 9], Mental Disorders, Case-control study, Paternal age, Retrospective cohort study, Middle Aged, medicine.disease, Psychiatry and Mental health, Logistic Models, Child Development Disorders, Pervasive, Schizophrenia, Case-Control Studies, Major depressive disorder, Autism, Female, Psychology, Functional Neurogenomics [DCN 2], Clinical psychology |
| الوصف: | We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population.In total, 14231 patients and 56924 matched controls were collected and analyzed for an association with paternal age by logistic regression.ASD is significantly associated with increased paternal age: Older fathers40 years of age have a 3.3 times increased odds of having a child with ASD compared to young fathers20 years of age. SCZ has significant associations for fathers aged35 years (OR=1.27, 95% Confidence Interval: 1.05 and 1.53). For MDD, both younger and older fathers have increased odds. No association was found for BPD.The effects of paternal age as a risk factor are different for ASD and SCZ on one hand, and the affective disorders on the other hand. Different types of association might indicate different biological or psychosocial mechanisms. Late paternity (associated with predispositions to psychiatric disorders) seems the most probable explanation for the association with paternal age. |
| تدمد: | 0920-9964 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbc4dd1ec8fcfb2e16bf037bbd4727ef https://hdl.handle.net/2066/98190 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fbc4dd1ec8fcfb2e16bf037bbd4727ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09209964 |
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