Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year
| العنوان: | Effects of off-pump and on-pump coronary-artery bypass grafting at 1 year |
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| المؤلفون: | Salim Yusuf, Sukesh Reddy, Balram Airan, Richard P. Whitlock, Yongning Ou, Dorairaj Prabhakaran, Susan Chrolavicius, Ernesto Paolasso, Philip J. Devereaux, Toomas-Andres Sulling, Andre Lamy, Liang Tao, Shengshou Hu, Janice Pogue, David P. Taggart, Chandrasekar Padmanabhan, Richard J. Novick, Juan-Carlos Bahamondes, Zbynek Straka, Leopoldo S. Piegas, Anil Jain, Pablo A. Olavegogeascoechea, Ahmet Rüçhan Akar, Prashant Vaijyanath, Nicolas Noiseux |
| المساهمون: | University of Zurich, Lamy, André |
| المصدر: | The New England journal of medicine. 368(13) |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Bypass grafting, Proportional hazards model, business.industry, Hazard ratio, 610 Medicine & health, General Medicine, 2700 General Medicine, Confidence interval, law.invention, 10020 Clinic for Cardiac Surgery, medicine.anatomical_structure, Randomized controlled trial, Quality of life, law, Internal medicine, Cardiology, medicine, business, Neurocognitive, Artery |
| الوصف: | BACKGROUND: Previously, we reported that there was no significant difference at 30 days in the rate of a primary composite outcome of death, myocardial infarction, stroke, or new renal failure requiring dialysis between patients who underwent coronary-artery bypass grafting (CABG) performed with a beating-heart technique (off-pump) and those who underwent CABG performed with cardiopulmonary bypass (on-pump). We now report results on quality of life and cognitive function and on clinical outcomes at 1 year. METHODS: We enrolled 4752 patients with coronary artery disease who were scheduled to undergo CABG and randomly assigned them to undergo the procedure off-pump or on-pump. Patients were enrolled at 79 centers in 19 countries. We assessed quality of life and cognitive function at discharge, at 30 days, and at 1 year and clinical outcomes at 1 year. RESULTS: At 1 year, there was no significant difference in the rate of the primary composite outcome between off-pump and on-pump CABG (12.1% and 13.3%, respectively; hazard ratio with off-pump CABG, 0.91; 95% confidence interval [CI], 0.77 to 1.07; P=0.24). The rate of the primary outcome was also similar in the two groups in the period between 31 days and 1 year (hazard ratio, 0.79; 95% CI, 0.55 to 1.13; P=0.19). The rate of repeat coronary revascularization at 1 year was 1.4% in the off-pump group and 0.8% in the on-pump group (hazard ratio, 1.66; 95% CI, 0.95 to 2.89; P=0.07). There were no significant differences between the two groups at 1 year in measures of quality of life or neurocognitive function. CONCLUSIONS: At 1 year after CABG, there was no significant difference between off-pump and on-pump CABG with respect to the primary composite outcome, the rate of repeat coronary revascularization, quality of life, or neurocognitive function. (Funded by the Canadian Institutes of Health Research; CORONARY ClinicalTrials.gov number, NCT00463294.). |
| وصف الملف: | nejmoa1301228.pdf - application/pdf |
| اللغة: | English |
| تدمد: | 1533-4406 0028-4793 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8464d829a7ef7b52698b6587e17f9f http://ora.ox.ac.uk/objects/uuid:94860cfe-cb2b-464d-8cf1-13fbae7756a6 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fb8464d829a7ef7b52698b6587e17f9f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15334406 00284793 |
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