NBD-Based Environment-Sensitive Fluorescent Probes for the Human Ether-a-Go-Go–Related Gene Potassium Channel
| العنوان: | NBD-Based Environment-Sensitive Fluorescent Probes for the Human Ether-a-Go-Go–Related Gene Potassium Channel |
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| المؤلفون: | Lijuan Chai, Gaopan Dong, Lupei Du, Qi Li, Xiaomeng Zhang |
| المصدر: | Frontiers in Molecular Biosciences, Vol 8 (2021) Frontiers in Molecular Biosciences |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | congenital, hereditary, and neonatal diseases and abnormalities, Fluorophore, small-molecule fluorescent probe, QH301-705.5, hERG, hERG potassium channel, 010402 general chemistry, Fluorescent imaging, 01 natural sciences, Biochemistry, Genetics and Molecular Biology (miscellaneous), Biochemistry, HUMAN ETHER-A-GO-GO-RELATED GENE, chemistry.chemical_compound, cell imaging, Molecular Biosciences, cardiovascular diseases, Biology (General), Molecular Biology, Original Research, biology, 010405 organic chemistry, fluorescent imaging, Fluorescence, Potassium channel, 0104 chemical sciences, fluorescent labeling technology, Fluorescent labelling, chemistry, Biophysics, biology.protein |
| الوصف: | Three environment-sensitive probes were developed for the hERG channel based on the nitrobenzoxadiazole fluorophore herein. After careful evaluation, probes M1 and M3 were found to have a high affinity for imaging the hERG channel in the cell-based experiment. Compared with other fluorescent labeling technologies (such as fluorescent proteins), these probes afford a convenient and economical method to determine hERG channel in vitro and in cellulo. Therefore, these probes are expected to be applicable for usage in physiological and pathological studies of hERG channels and have the potential to establish a screening system for hERG channels. |
| اللغة: | English |
| DOI: | 10.3389/fmolb.2021.666605/full |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa73c8b1b81f6caf85a00b109bedb2b5 https://www.frontiersin.org/articles/10.3389/fmolb.2021.666605/full |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fa73c8b1b81f6caf85a00b109bedb2b5 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.3389/fmolb.2021.666605/full |
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