التفاصيل البيبلوغرافية
| العنوان: |
Radiochemotherapy upregulates expression of checkpoint receptors on circulating T cells |
| المؤلفون: |
Yinping Dong, Heng-Hong Li, Yun-Tien Lin, Yuanyang Zhang, Zhiyong Yuan, Albert J. Fornace, Yong Guan, Renxiang Chen, Deguan Li, Jing Wu |
| بيانات النشر: |
Taylor & Francis, 2021. |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
Chemokine, T-Lymphocytes, Lymphocyte, Programmed Cell Death 1 Receptor, Flow cytometry, Humans, Medicine, Cytotoxic T cell, CTLA-4 Antigen, Radiology, Nuclear Medicine and imaging, Lymphocyte Count, Receptor, Cervical cancer, Radiological and Ultrasound Technology, biology, medicine.diagnostic_test, business.industry, Cancer, Chemoradiotherapy, Esophageal cancer, medicine.disease, medicine.anatomical_structure, biology.protein, Cancer research, Cytokines, business |
| الوصف: |
PURPOSE This study assesses changes of circulating leukocyte subpopulations and the expression of checkpoint receptors in T cells in patients undergoing radiochemotherapy. MATERIALS AND METHODS Fifty-seven patients with either esophageal cancer or cervical cancer who received radiochemotherapy were recruited into this study. Serial blood collection was carried out before and during treatments. Leukocyte subpopulations and the level of PD-1 and CTLA-4 in T cells were determined by flow cytometry. The plasma concentrations of 34 human cytokines, chemokines, and growth factors were quantified. RESULTS Significant decreases of lymphocyte count and percentage of T cells and B cells were observed during radiochemotherapy. Percentages of PD-1hi and CTLA-4hi populations in T cells increased after treatments. Proportion of activated T cells showed no significant difference. No significant changes in the plasma concentrations of the 34 humoral mediators except mild decreases of six cytokines. CONCLUSION Elevated expression of PD-1 and CTLA-4 in T cells in patients receiving radiochemotherapy, which suggests that exhaustion-like T-cell dysfunction develops during cancer cytotoxic treatments. |
| DOI: |
10.6084/m9.figshare.15178991 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9338ed9fac93935f030fe91ef3e8f47 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....f9338ed9fac93935f030fe91ef3e8f47 |
| قاعدة البيانات: |
OpenAIRE |