Crystal structure of the large subunit of cobaltochelatase from Mycobacterium tuberculosis
| العنوان: | Crystal structure of the large subunit of cobaltochelatase from |
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| المؤلفون: | Lin Liu, Xiao Wang, Jia‐Hui Zhang, Huai-En Dai, Min Zhang, Hui Yuan |
| المصدر: | Proteins: Structure, Function, and Bioinformatics. 89:462-467 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Models, Molecular, Cobalamin biosynthesis, Protein subunit, Cobaltochelatase, Lyases, Crystal structure, Biochemistry, Cobalamin, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Protein Domains, Structural Biology, Molecular Biology, 030304 developmental biology, 0303 health sciences, Crystallography, biology, Chemistry, 030302 biochemistry & molecular biology, Significant difference, biology.organism_classification, Magnesium chelatase |
| الوصف: | Cobaltochelatase in aerobic cobalamin biosynthesis is a complex composed of three subunits. The large subunit CobN is a 140-kDa protein and is homologous to the ChlH subunit of magnesium chelatase. Previously we have reported the 2.5-Å structure of a cyanobacterial ChlH. Here we present the 1.8-Å structure of CobN from Mycobacterium tuberculosis. The overall structure of CobN and ChlH is similar, but significant difference occurs in the head domain. Structural comparison of domains between the two proteins unravels candidate regions for substrate binding and helps to locate a triad of residues that may be essential for metal ion binding. |
| تدمد: | 1097-0134 0887-3585 |
| DOI: | 10.1002/prot.26023 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83cdabdf074bb515ec4f88f99523046 https://doi.org/10.1002/prot.26023 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f83cdabdf074bb515ec4f88f99523046 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970134 08873585 |
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| DOI: | 10.1002/prot.26023 |