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miR-10b promotes aortic aneurysm formation and aortic rupture in angiotensin II-induced ApoE-deficient mice

التفاصيل البيبلوغرافية
العنوان: miR-10b promotes aortic aneurysm formation and aortic rupture in angiotensin II-induced ApoE-deficient mice
المؤلفون: Anne Kunath, Dick Wågsäter, Kevin Mani, Anders Wanhainen, Mediha Becirovic Agic, Amanda Balboa Ramilo, Mikaela Näsström, Marcelo Heron Petri
بيانات النشر: Uppsala universitet, Institutionen för medicinsk cellbiologi, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Apolipoprotein E, medicine.medical_specialty, Apolipoprotein B, Mice, Knockout, ApoE, Physiology, Aortic Rupture, Mice, Aortic aneurysm, Aneurysm, Internal medicine, medicine.artery, medicine, Animals, Cardiac and Cardiovascular Systems, Aorta, Abdominal, Aortic rupture, Aorta, Pharmacology, Kardiologi, biology, microRNA, business.industry, Angiotensin II, medicine.disease, Abdominal aortic aneurysm, Mice, Inbred C57BL, Treatment, Disease Models, Animal, MicroRNAs, Endocrinology, biology.protein, cardiovascular system, Molecular Medicine, business, miR-10b, Aortic Aneurysm, Abdominal
الوصف: Abdominal aortic aneurysm (AAA) is associated with increased plasma levels of microRNA (miR) -10b. 5 nmols of miR-10b or miR control was administrated to Apolipoprotein E-deficient mice three days prior implantation of osmotic mini-pumps containing angiotensin II, and for three additional times once a week, which increased expression of miR-10b in plasma. Animals receiving miR-10b had a mortality rate due to aortic rupture of 61% compared to 11% in the miR controls (p De två första författarna delar förstaförfattarskapet.
وصف الملف: application/pdf
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f818fb5b1c73efc9d6065576d34e2fd7
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-459191
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....f818fb5b1c73efc9d6065576d34e2fd7
قاعدة البيانات: OpenAIRE
الوصف
الوصف غير متاح.