The Lymphatic Drainage Pattern of Internal Mammary Sentinel Lymph Node Identified by Small Particle Radiotracer (99mTc-Dextran 40) in Breast
| العنوان: | The Lymphatic Drainage Pattern of Internal Mammary Sentinel Lymph Node Identified by Small Particle Radiotracer (99mTc-Dextran 40) in Breast |
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| المؤلفون: | Bin-Bin Cong, Peng-Fei Qiu, Guo-Ren Yang, Xiao-Shan Cao, Yong-Sheng Wang |
| المصدر: | Cancer Research and Treatment : Official Journal of Korean Cancer Association |
| بيانات النشر: | Korean Cancer Association, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Internal mammary sentinel lymph node, Adult, 0301 basic medicine, Cancer Research, Sentinel lymph node, Breast Neoplasms, Mice, 03 medical and health sciences, 0302 clinical medicine, Biopsy, medicine, Lymphatic vessel, Animals, Humans, Small particles, Radioactive Tracers, Lymph node, Aged, Breast Density, Neoplasm Staging, Tomography, Emission-Computed, Single-Photon, medicine.diagnostic_test, business.industry, 99mTc-Dextran 40, Technetium, Dextrans, SPECT/CT, Middle Aged, Disease Models, Animal, Lymph drainage, 030104 developmental biology, medicine.anatomical_structure, Lymphatic system, Oncology, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Heterografts, Original Article, Female, Lymph, Sentinel Lymph Node, Tomography, X-Ray Computed, Nuclear medicine, business, Emission computed tomography |
| الوصف: | Purpose The purpose of this study was to detect the lymphatic drainage pattern of internal mammary area and verify the concept of internal mammary sentinel lymph node (IM-SLN) in breast. Materials and methods A small particle radiotracer (99mTc-Dextran 40) was prepared and tested. 99mTc-Dextran 40 was injected into intraparenchyma at the sound breast by a modified radiotracer injection technique. Subsequently, dynamic single-photon emission computed tomography (SPECT), computed tomography (CT), and SPECT/CT combination images were performed to identify the radioactive lymph vessels and internal mammary lymph nodes (IMLNs). The direction of lymph drainage and the location of the IMLNs were identified in the SPECT/CT imaging. Results The radiochemical purity of 99mTc-Dextran 40 was > 95%. 99mTc-Dextran 40 could drainage into first, second, and third lymph node and the radioactive lymph node could be detected by the γ detector in the animal experiment. After 99mTc-Dextran 40 injecting into intraparenchyma, 50.0% cases (15/30) were identified the drainage lymphatic vessels and radioactive IMLNs by SPECT. The drainage lymphatic vessel was found from injection point to the first IMLN (IM-SLN) after 10.5±0.35 minutes radiotracer injection, and then 99mTc-Dextran 40 was accumulated into the IM-SLN. The combination imaging of SPECT/CT showed the second IMLN received the lymph drainage from the IM-SLN. The lymphatic drainage was step by step in the internal mammary area. Conclusion The lymph was identified to drain from different regions of the breast to IM-SLN, and then outward from IM-SLN to other IMLN consecutively. It demonstrated the concept of the IM-SLN and provided more evidences for the application of internal mammary sentinel lymph node biopsy. |
| تدمد: | 2005-9256 1598-2998 |
| DOI: | 10.4143/crt.2018.062 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f808e6f574baf21a092c304ff1b70a32 https://doi.org/10.4143/crt.2018.062 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f808e6f574baf21a092c304ff1b70a32 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20059256 15982998 |
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| DOI: | 10.4143/crt.2018.062 |