Breast cancer risk in BRCA1/2 mutation carriers and noncarriers under prospective intensified surveillance
| العنوان: | Breast cancer risk in BRCA1/2 mutation carriers and noncarriers under prospective intensified surveillance |
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| المؤلفون: | Barbara Wappenschmidt, Eva Maria Fallenberg, N Herold, Kerstin Rhiem, Denise Horn, Stefanie Pertschy, Karin Kast, Achim Wöckel, Ulrike Siebers-Renelt, Susanne Briest, Marion Kiechle, Walter Just, Christoph Engel, Claus R. Bartram, Markus Loeffler, Dorothee Speiser, Christoph Mundhenke, Karolin Bucksch, AS Vesper, Silke Zachariae, Pauline Wimberger, M Maringa, Nicola Dikow, Jutta Giesecke, Brigitte Schlegelberger, Elena Leinert, Sarah Schott, Eric Hahnen, Ulrich Bick, Rita K. Schmutzler, Anne S. Quante, Simone Reichstein-Gnielinski, Norbert Arnold, Stefanie Weigel, Christine Fischer, Verena Hübbel, Andrea Gehrig, Tanja Fehm |
| المصدر: | International Journal of Cancer. 146:999-1009 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Heterozygote, Cancer Research, medicine.medical_specialty, Population, Breast Neoplasms, Risk Assessment, Contralateral breast cancer, 03 medical and health sciences, Brca1 2 mutation, 0302 clinical medicine, Breast cancer, Risk Factors, Germany, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Prospective Studies, Family history, Medical History Taking, skin and connective tissue diseases, education, Prospective cohort study, BRCA2 Protein, education.field_of_study, BRCA1 Protein, business.industry, Incidence, Age Factors, Middle Aged, medicine.disease, Oncology, 030220 oncology & carcinogenesis, Epidemiological Monitoring, Mutation, Mutation (genetic algorithm), Female, Ovarian cancer, business, Follow-Up Studies |
| الوصف: | Comparably little is known about breast cancer (BC) risks in women from families tested negative for BRCA1/2 mutations despite an indicative family history, as opposed to BRCA1/2 mutation carriers. We determined the age-dependent risks of first and contralateral breast cancer (FBC, CBC) both in noncarriers and carriers of BRCA1/2 mutations, who participated in an intensified breast imaging surveillance program. The study was conducted between January 1, 2005, and September 30, 2017, at 12 university centers of the German Consortium for Hereditary Breast and Ovarian Cancer. Two cohorts were prospectively followed up for incident FBC (n = 4,380; 16,398 person-years [PY], median baseline age: 39 years) and CBC (n = 2,993; 10,090 PY, median baseline age: 42 years). Cumulative FBC risk at age 60 was 61.8% (95% CI 52.8-70.9%) for BRCA1 mutation carriers, 43.2% (95% CI 32.1-56.3%) for BRCA2 mutation carriers and 15.7% (95% CI 11.9-20.4%) for noncarriers. FBC risks were significantly higher than in the general population, with incidence rate ratios of 23.9 (95% CI 18.9-29.8) for BRCA1 mutation carriers, 13.5 (95% CI 9.2-19.1) for BRCA2 mutation carriers and 4.9 (95% CI 3.8-6.3) for BRCA1/2 noncarriers. Cumulative CBC risk 10 years after FBC was 25.1% (95% CI 19.6-31.9%) for BRCA1 mutation carriers, 6.6% (95% CI 3.4-12.5%) for BRCA2 mutation carriers and 3.6% (95% CI 2.2-5.7%) for noncarriers. CBC risk in noncarriers was similar to women with unilateral BC from the general population. Further studies are needed to confirm whether less intensified surveillance is justified in women from BRCA1/2 negative families with elevated risk. |
| تدمد: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.32396 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f796bcd845b569e4e6347529d6276e2b https://doi.org/10.1002/ijc.32396 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f796bcd845b569e4e6347529d6276e2b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
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| DOI: | 10.1002/ijc.32396 |