Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination?
| العنوان: | Pneumococcal serotype distribution in adults with invasive disease and in carrier children in Italy: Should we expect herd protection of adults through infants' vaccination? |
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| المؤلفون: | Massimo Edoardo Di Natale, D. Aquilini, Guglielmo Consales, Maria Moriondo, Massimo Resti, Angela Pasinato, Francesco Nieddu, Romano Mattei, Giancarlo Bini, Chiara Azzari, Silvia Ricci, Roberto Degl'Innocenti, Elisa De Vitis, Martina Cortimiglia, Beatrice Adriani, Massimo Zuliani, Giusi Mangone, Clementina Canessa, Angela Bechini, Paolo Bonanni, Giuseppe Indolfi |
| المصدر: | Human Vaccines & Immunotherapeutics |
| بيانات النشر: | Taylor & Francis, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | 0301 basic medicine, Serotype, nasopharyngeal carriage, Immunity, Herd, Pediatrics, Heptavalent Pneumococcal Conjugate Vaccine, medicine.disease_cause, Pneumococcal conjugate vaccine, Pneumococcal Vaccines, 0302 clinical medicine, vaccine, Nasopharynx, Immunology and Allergy, herd-protection, 030212 general & internal medicine, Child, Vaccination, Middle Aged, Pneumococcal infections, Streptococcus pneumoniae, Italy, Child, Preschool, Carrier State, medicine.drug, Research Paper, Adult, medicine.medical_specialty, 030106 microbiology, Immunology, Serogroup, invasive pneumococcal disease, Herd immunity, Realtime PCR, 03 medical and health sciences, medicine, Humans, Aged, Pharmacology, Vaccines, Conjugate, business.industry, Immunization Programs, pneumococcal serotype, Pneumonia, Pneumococcal, medicine.disease, Pneumococcal vaccine, business |
| الوصف: | The 7-valent pneumococcal conjugate vaccine (PCV7) produced a significant herd protection in unvaccinated adult population mostly because of pneumococcus carriage decrease in vaccinated children. It is not known if the 13-valent pneumococcal vaccine can give similar effect on adults. Aims of the work were to evaluate whether the 6 additional serotypes are present in nasopharynx of children and serotype distribution in invasive pneumococcal infections (IPD) in adults. Realtime-PCR was used to evaluate pneumococcal serotypes in adults with confirmed IPD and in nasopharyngeal swabs (NP) from 629 children not vaccinated or vaccinated with PCV7 and resident in the same geographical areas. Two hundred twenty-one patients (116 males, median 67.9 years) with IPD were studied (pneumonia n = 103, meningitis n = 61 sepsis n = 50, other n = 7). Two hundred twelve were serotyped. The most frequent serotypes were 3, (31/212; 14.6%), 19A, (19/212; 9.0%), 12 (17/212; 8.0%), 7F, (14/212; 6.6%). In NP of children, the frequency of those serotypes causing over 50% of IPD in adults was very low, ranging from 0.48% for serotype 7F to 7.9% for serotype 19A. On the other side serotype 5, very frequent in NP (18.7%) caused |
| اللغة: | English |
| تدمد: | 2164-554X 2164-5515 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72864747d3e53abcb517f785541fdc9 http://europepmc.org/articles/PMC5049737 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f72864747d3e53abcb517f785541fdc9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2164554X 21645515 |
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