Comparative genomics of Salmonella enterica serovar Enteritidis ST-11 isolated in Uruguay reveals lineages associated with particular epidemiological traits
| العنوان: | Comparative genomics of Salmonella enterica serovar Enteritidis ST-11 isolated in Uruguay reveals lineages associated with particular epidemiological traits |
|---|---|
| المؤلفون: | Derek Pickard, Laura Betancor, Lucía Balestrazzi, Florencia Grattarola, Lucía Yim, Bruno D'Alessandro, José A. Chabalgoity, Victoria Pérez Escanda, Andrés Iriarte |
| المساهمون: | D’Alessandro Bruno, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene., Pérez Escanda Victoria, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene., Balestrazzi Lucía, Universidad de la República (Uruguay). Facultad de Ciencias. Instituto de Biología. Université Paris 7, Grattarola Florencia, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene, Iriarte Andrés, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene, Pickard D., Yim Lucía, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene, Chabalgoity José Alejandro, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene, Betancor Laura, Universidad de la República (Uruguay). Facultad de Medicina. Instituto de Higiene |
| المصدر: | COLIBRI Universidad de la República instacron:Universidad de la República Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Serotype, Lineage (evolution), 030106 microbiology, lcsh:Medicine, Biology, Genome, Article, Disease Outbreaks, Phylogenetic, 03 medical and health sciences, Bacterial Proteins, Phylogenetics, Humans, lcsh:Science, Phylogeny, Bacterial genomics, Comparative genomics, Genetics, Multidisciplinary, Phylogenetic tree, lcsh:R, Outbreak, Salmonella enterica serovar Enteritidis, Publisher Correction, 030104 developmental biology, Salmonella enteritidis, Salmonella Infections, Uruguay, Multilocus sequence typing, lcsh:Q, Multilocus Sequence Typing |
| الوصف: | Salmonella enterica serovar Enteritidis is a major cause of foodborne disease in Uruguay since 1995. We used a genomic approach to study a set of isolates from different sources and years. Whole genome phylogeny showed that most of the strains are distributed in two major lineages (E1 and E2), both belonging to MLST sequence type 11 the major ST among serovar Enteritidis. Strikingly, E2 isolates are over-represented in periods of outbreak abundance in Uruguay, while E1 span all epidemic periods. Both lineages circulate in neighbor countries at the same timescale as in Uruguay, and are present in minor numbers in distant countries. We identified allelic variants associated with each lineage. Three genes, ycdX, pduD and hsdM, have distinctive variants in E1 that may result in defective products. Another four genes (ybiO, yiaN, aas, aceA) present variants specific for the E2 lineage. Overall this work shows that S. enterica serovar Enteritidis strains circulating in Uruguay have the same phylogenetic profile than strains circulating in the region, as well as in more distant countries. Based on these results we hypothesize that the E2 lineage, which is more prevalent during epidemics, exhibits a combination of allelic variants that could be associated with its epidemic ability. |
| وصف الملف: | application/pdf |
| تدمد: | 2045-2322 |
| DOI: | 10.1038/s41598-020-60502-8 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6dc86e7a6eaa3d46219f93040d0aeb6 https://doi.org/10.1038/s41598-020-60502-8 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f6dc86e7a6eaa3d46219f93040d0aeb6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|---|
| DOI: | 10.1038/s41598-020-60502-8 |