Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil
| العنوان: | Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil |
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| المؤلفون: | Hitesh H. Bulchandani, Chhaganbhai N. Patel, Shailesh T. Prajapati, Dashrath M. Patel, Suresh K. Dumaniya |
| المصدر: | Journal of Drug Delivery, Vol 2013 (2013) Journal of Drug Delivery |
| بيانات النشر: | Hindawi Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Drug, Chromatography, Article Subject, business.industry, media_common.quotation_subject, lcsh:RS1-441, Pharmacology, lcsh:Pharmacy and materia medica, medicine, Drug release, Olmesartan, business, Dissolution, Research Article, media_common, medicine.drug, Absolute bioavailability |
| الوصف: | Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. It is highly lipophilic (log P 5.5) and a poorly water-soluble drug with absolute bioavailability of 26%. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate. Liquisolid compacts were prepared using Acrysol El 135 as a solvent, Avicel PH 102, Fujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios. The interaction between drug and excipients was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients. The powder characteristics were evaluated by different flow parameters to comply with pharmacopoeial limits. The dissolution studies for liquisolid compacts and conventional formulations were carried out, and it was found that liquisolid compacts with 80% w/w of Acrysol EL 135 to the drug showed significant higher drug release rates than conventional tablets. Amongst carriers used Fujicalin and Neusilin were found to be more effective carrier materials for liquid adsorption. |
| وصف الملف: | text/xhtml |
| تدمد: | 2090-3022 2090-3014 |
| DOI: | 10.1155/2013/870579 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a42872cfe6b1038f4cc799675a55a0 https://doi.org/10.1155/2013/870579 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f6a42872cfe6b1038f4cc799675a55a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20903022 20903014 |
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| DOI: | 10.1155/2013/870579 |