Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion island
| العنوان: | Persistent arthralgia associated with chikungunya virus: a study of 88 adult patients on reunion island |
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| المؤلفون: | Annie Jossaume, Gianandrea Borgherini, P. Poubeau, Arnaud Gouix, Liliane Cotte, F. Paganin, Alain Michault, C. Arvin-Berod |
| المساهمون: | Service des Maladies Infectieuses, CHR la Reunion site Sud, Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Réunion (GHSR), CIC régional épidémiologie clinique/essais cliniques - Ile de la Réunion (CIC-EC), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre d'Investigation Clinique de La Réunion - INSERM (CIC 1410), Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Laboratoire de Bactériologie, Virologie et Parasitologie [Saint-Pierre, La Réunion], Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), Univ, Réunion |
| المصدر: | Clinical Infectious Diseases Clinical Infectious Diseases, Oxford University Press (OUP), 2008, 47 (4), pp.469-475. ⟨10.1086/590003⟩ |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Microbiology (medical), Male, medicine.medical_specialty, viruses, 030231 tropical medicine, Population, Disease, medicine.disease_cause, Antibodies, Viral, Virus, Disease Outbreaks, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Prevalence, Humans, Chikungunya, education, 030304 developmental biology, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, 0303 health sciences, education.field_of_study, Adult patients, business.industry, Alphavirus Infections, Outbreak, virus diseases, Middle Aged, Arthralgia, 3. Good health, Infectious Diseases, Immunoglobulin M, Joint pain, Immunology, Cohort, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, Female, France, medicine.symptom, business, Chikungunya virus |
| الوصف: | International audience; Background: An outbreak of chikungunya virus infection occurred on Reunion Island during the period 2005-2006. Persistent arthralgia after chikungunya virus infection has been reported, but few studies have treated this aspect of the disease.Methods: Adult patients with laboratory-confirmed acute chikungunya virus infection who were referred to Groupe Hospitalier Sud Reunion during the period 2005-2006 were asked to participate in the study. Patients were assessed a mean of 18 months after acute disease occurred. Assessment consisted of answering questions on a standard form, undergoing a medical examination, and being tested for the presence of IgM antibodies to chikungunya virus.Results: Eighty-eight patients (mean age, 58.3 years; male-to-female ratio, 1.1:1.0) were included in this study. Fifty-eight patients (65.9%) had been hospitalized for acute chikungunya virus infection, and a history of arthralgia before chikungunya virus infection was reported by 39 patients (44%). Fifty-six patients (63.6%) reported persistent arthralgia related to chikungunya virus infection, and in almost one-half of the patients, the joint pain had a negative impact on everyday activities. Arthralgia was polyarticular in all cases, and pain was continuous in 31 patients (55.4%). Overall, 35 patients (39.7%) had test results positive for IgM antibodies to chikungunya virus.Conclusions: Persistent and disabling arthralgia was a frequent concern in this cohort of patients who had experienced severe chikungunya virus infection approximately 18 months earlier. Further studies are needed to evaluate the prevalence of persistent arthralgia in the general population to determine the real burden of the disease. |
| تدمد: | 1537-6591 2005-2006 1058-4838 |
| DOI: | 10.1086/590003⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f68591607f0dc65358c5b0ff4b646070 https://pubmed.ncbi.nlm.nih.gov/18611153 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f68591607f0dc65358c5b0ff4b646070 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 20052006 10584838 |
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| DOI: | 10.1086/590003⟩ |