The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence
| العنوان: | The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence |
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| المؤلفون: | T.K. Lee, Irene Oi-Lin Ng, ST Fan, Kevin Tak-Pan Ng, Bai Shun Sun, Chi-Leung Liu, Ronnie Tp Poon, Joanna W. Ho, Chris K. Sun, Kwan Man, Chung Mau Lo |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Cancer Research, Pathology, medicine.medical_specialty, Carcinoma, Hepatocellular, Lung Neoplasms, recurrence, disease-free survival, invasiveness, Mice, Nude, Biology, Metastasis, Liver Neoplasms - enzymology - genetics, Focal adhesion, Mice, Ezrin, Cell Line, Tumor, medicine, Animals, Humans, Neoplasm Invasiveness, Neoplasm Metastasis, Cell Proliferation, Carcinoma, Hepatocellular - enzymology - genetics, Reverse Transcriptase Polymerase Chain Reaction, Cell growth, Liver Neoplasms, proline-rich tyrosine kinase2 (Pyk2), hepatocellular carcinoma, Prognosis, medicine.disease, Focal Adhesion Kinase 2 - metabolism, Fibronectins, Cytoskeletal Proteins, Focal Adhesion Kinase 2, Oncology, Tyrosine kinase 2, Focal Adhesion Kinase 1, Hepatocellular carcinoma, Cancer cell, Disease Progression, Cancer research, Neoplasm Recurrence, Local, Translational Therapeutics, Liver cancer, Neoplasm Transplantation |
| الوصف: | Understanding the precise molecular mechanisms that trigger liver cancer cell migration and invasion could develop novel therapeutic strategies targeting cancer cell invasion to increase the sensitivity to current treatment modalities. In the current study, 49 patients with hepatocellular carcinoma (HCC) were included prospectively. Liver tumour and adjacent non-tumour tissues were detected for the expression of Proline-rich tyrosine kinase 2 (Pyk2), focal adhesion kinase (FAK), ezrin and fibronectin at protein and/or gene levels. Correlation between the expressions of Pyk2/FAK with the clinical pathological data was analysed. Protein expression of Pyk2 was also examined in a nude mice orthotopic liver tumour model with higher metastatic potential. There were 59% (29 out of 49) and 57% (28 out of 49) of HCC patients with higher levels of Pyk2 and FAK protein/gene expression, respectively. We observed a positive correlation between the protein and gene expression levels of Pyk2 and FAK (P=0.000, r=0.875). Overexpression of Pyk2 and FAK was significantly correlated with shorter disease-free survival. Patients with higher levels of Pyk2/FAK had larger tumour size and advanced Edmonson grading. In the animal studies, Pyk2 overexpression was found in infiltrative tumour cells and lung metastatic nodules. In conclusion, overexpression of Pyk2 and FAK was found in nearly 60% of HCC patients and was significantly correlated with poor prognosis. The significance of Pyk2 in HCC invasiveness was confirmed by animal studies. © 2007 Cancer Research UK. published_or_final_version |
| تدمد: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6603827 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f667c68efd3e7531893273d5cc084035 https://doi.org/10.1038/sj.bjc.6603827 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f667c68efd3e7531893273d5cc084035 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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| DOI: | 10.1038/sj.bjc.6603827 |