Modelling of the 177mLu/177Lu radionuclide generator

التفاصيل البيبلوغرافية
العنوان: Modelling of the 177mLu/177Lu radionuclide generator
المؤلفون: Antonia G. Denkova, Pablo Serra-Crespo, Hubert Th. Wolterbeek, Rupali Bhardwaj
المصدر: Applied Radiation and Isotopes, 166
سنة النشر: 2020
مصطلحات موضوعية: Lutetium-177 radionuclide generator radionuclide production, Work (thermodynamics), Radiation, Chemistry, business.industry, Dissociation rate, Technical specifications, 010403 inorganic & nuclear chemistry, 01 natural sciences, 030218 nuclear medicine & medical imaging, 0104 chemical sciences, Separation process, 03 medical and health sciences, 0302 clinical medicine, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Production (economics), Specific activity, Dissociation kinetics, Radionuclide Generator, Process engineering, business
الوصف: In order to determine the potential of 177mLu/177Lu radionuclide generator in 177Lu production it is important to establish the technical needs that can lead to a clinically acceptable 177Lu product quality. In this work, a model that includes all the processes and the parameters affecting the performance of the 177mLu/177Lu radionuclide generator has been developed. The model has been based on the use of a ligand to complex 177mLu ions, followed by the separation of the freed 177Lu ions. The dissociation kinetics of the Lu-ligand complex has been found to be the most crucial aspect governing the specific activity and 177mLu content of the produced 177Lu. The dissociation rate constants lower than 1*10-11 s-1 would be required to lead to onsite 177Lu production with specific activity close to theoretical maximum of 4.1 TBq 177Lu/mg Lu and with 177mLu content of less than 0.01%. Lastly, the calculations suggest that more than one patient dose per week can be supplied for a period of up to 7 months on starting with the 177mLu produced using 3 g Lu2O3 target with 60% 176Lu enrichment. The requirements of the starting 177mLu activity production needs to be adapted depending on the required patient doses, and the technical specifications of the involved 177mLu-177Lu separation process.
وصف الملف: application/pdf
اللغة: English
تدمد: 0969-8043
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f613a32d416f4391a8a2b0841105d01f
http://resolver.tudelft.nl/uuid:117e2802-59d6-49dc-bc86-be6b39b76994
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....f613a32d416f4391a8a2b0841105d01f
قاعدة البيانات: OpenAIRE