Redispersible Spray-Dried Powder Containing Nanoencapsulated Curcumin: the Drying Process Does Not Affect Neuroprotection In vitro
| العنوان: | Redispersible Spray-Dried Powder Containing Nanoencapsulated Curcumin: the Drying Process Does Not Affect Neuroprotection In vitro |
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| المؤلفون: | Diego Fontana de Andrade, Irene Clemes Külkamp-Guerreiro, Branko Vukosavljevic, Christianne Gazzana Salbego, Juliana Bender Hoppe, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterres, Maike Windbergs, Ruy Carlos Ruver Beck |
| المساهمون: | HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany., TWINCORE, Zentrum für experimentelle und klinische Infektionsforschung GmbH,Feodor-Lynen Str. 7, 30625 Hannover, Germany. |
| المصدر: | AAPS PharmSciTech United States |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | powders, Male, Curcumin, medicine.medical_treatment, Pharmaceutical Science, Administration, Oral, 02 engineering and technology, Aquatic Science, In Vitro Techniques, 030226 pharmacology & pharmacy, Hippocampus, Nanocapsules, neuroinflammation, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Oral administration, Polysaccharides, Drug Discovery, medicine, Animals, curcumin, spray-drying, Desiccation, Particle Size, Rats, Wistar, Ecology, Evolution, Behavior and Systematics, Aqueous solution, Ecology, nanocapsules, General Medicine, 021001 nanoscience & nanotechnology, Maltodextrin, In vitro, Neuroprotection, chemistry, Spray drying, Powders, 0210 nano-technology, Agronomy and Crop Science, Adjuvant, Nuclear chemistry |
| الوصف: | A redispersible spray-dried formulation containing curcumin-loaded, lipid-core nanocapsules (LNC-C) was developed for oral administration. The neuroprotective activity of curcumin after the spray-drying process was evaluated in vitro. The spray-dried powder (SD-LNC-C) was produced using a drying adjuvant composed of a blend of maltodextrin and L-leucine (90:10 w/w). Acceptable process yield (~ 70%) and drug content (6.5 ± 0.2 mg g-1) were obtained. SD-LNC-C was formed by smooth, spherical-shaped particles, and confocal Raman analysis indicated the distribution of the LNC-C on the surface of the leucine/maltodextrin agglomerates. The surface of the agglomerates was formed by a combination of LNC-C and adjuvants, and laser diffraction showed that SD-LNC-C had adequate aqueous redispersion, with no loss of controlled drug release behaviour of LNC-C. The in vitro curcumin activity against the lipopolysaccharide (LPS)-induced proinflammatory response in organotypic hippocampal slice cultures was evaluated. Both formulations (LNC-C and SD-LNC-C) reduced TNF-α to similar levels. Therefore, neuroprotection of curcumin in vitro may be improved by nanoencapsulation followed by spray-drying, with no loss of this superior performance. Hence, the redispersible spray-dried powder proposed here represents a suitable approach for the development of innovative nanomedicines containing curcumin for the prevention/treatment of neurodegenerative diseases. |
| تدمد: | 1530-9932 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e32a5699cb6c857185d0d766a4bef6 https://pubmed.ncbi.nlm.nih.gov/31407115 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f5e32a5699cb6c857185d0d766a4bef6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15309932 |
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