Prenatal prediction of survival in congenital diaphragmatic hernia: An audit of postnatal outcomes

التفاصيل البيبلوغرافية
العنوان: Prenatal prediction of survival in congenital diaphragmatic hernia: An audit of postnatal outcomes
المؤلفون: Sarah Bouchard, Natasha G. Caminsky, Josée Trebichavsky, Robin T. Petroze, Pramod Puligandla, Jean-Martin Laberge, Annie Le-Nguyen, Sherif Emil
المصدر: Journal of pediatric surgery. 54(5)
سنة النشر: 2019
مصطلحات موضوعية: Male, medicine.medical_specialty, Canada, Referral, Directive Counseling, Gestational Age, Audit, Extracorporeal, Ultrasonography, Prenatal, 03 medical and health sciences, 0302 clinical medicine, Extracorporeal Membrane Oxygenation, 030225 pediatrics, Pediatric surgery, medicine, Humans, Lung, business.industry, Obstetrics, Infant, Newborn, Gestational age, Congenital diaphragmatic hernia, General Medicine, Organ Size, medicine.disease, Prognosis, Survival Rate, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Life support, Pediatrics, Perinatology and Child Health, Surgery, Female, business, Hernias, Diaphragmatic, Congenital, Lung Volume Measurements, Head
الوصف: Purpose Effective antenatal counseling in congenital diaphragmatic hernia (CDH) relies on proper measurement of prognostic indices. This quality initiative audited the accuracy of prenatal imaging with postnatal outcomes at two tertiary pediatric referral centers. Methods Prenatal lung–head ratio (LHR) and total fetal lung volume (TFLV) for CDH patients treated between 2006 and 2017 were retrieved. Study inclusion required at least one LHR or TFLV measurement between 24 and 32 weeks gestational age. Postnatal outcomes [mortality, extracorporeal life support (ECLS) need, patch repair, persistent pulmonary hypertension, oxygen requirement at 28 days] were abstracted from the Canadian Pediatric Surgery Network (CAPSNet) database and local chart review. Univariate and descriptive analyses were conducted. Results Eighty-two of 121 eligible CDH patients (68%) were included. Overall mortality, ECLS rates, and patch repair were 33%, 12.5%, and 45%, respectively. Lower LHR values correlated with increased rates of each outcome and persisted despite multiple measurements. Values obtained were higher than those in published schemata. LHR values > 45% were most associated with survival, avoidance of ECLS, and primary repair. TFLV values only correlated with mortality and patch repair. Conclusions This audit confirms that LHR and TFLV values predict CDH outcomes. However, absolute values obtained require careful interpretation and internal review. Level of evidence IV.
تدمد: 1531-5037
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5dcf15ad1ed07c0fe21eaa8a7ca50b3
https://pubmed.ncbi.nlm.nih.gov/30786991
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....f5dcf15ad1ed07c0fe21eaa8a7ca50b3
قاعدة البيانات: OpenAIRE