NCOG-23. PATIENT-REPORTED SYMPTOM BURDEN AND INTERFERENCE: A COMPARISON BETWEEN COVID-19 PANDEMIC YEAR AND NORMATIVE DATA IN PATIENTS WITH CENTRAL NERVOUS SYSTEM (CNS) TUMORS
| العنوان: | NCOG-23. PATIENT-REPORTED SYMPTOM BURDEN AND INTERFERENCE: A COMPARISON BETWEEN COVID-19 PANDEMIC YEAR AND NORMATIVE DATA IN PATIENTS WITH CENTRAL NERVOUS SYSTEM (CNS) TUMORS |
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| المؤلفون: | Alexa Christ, Amanda King, Mark R. Gilbert, Michael Timmer, James Rogers, Terri Armstrong, Nicole Lollo, Kayla Roche, Nicole Briceno, Jason Levine, Valentina Pillai, Brett Theeler, Matthew Lindsley, Heather Leeper, Jing Wu, Marta Penas-Prado, Lisa Boris, Anna Choi, Eric Burton, Elizabeth Vera, Jennifer Reyes, Marissa Panzer, Ewa Grajkowska, Alvina Acquaye, Varna Jammula, Lily Polskin |
| المصدر: | Neuro-Oncology |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Central nervous system, Symptom burden, 26th Annual Meeting & Education Day of the Society for Neuro-Oncology, Interference (genetic), medicine.anatomical_structure, Oncology, Pandemic, Medicine, Normative, AcademicSubjects/MED00300, In patient, AcademicSubjects/MED00310, Neurology (clinical), CNS TUMORS, business, Outcome Measures and Neuro-Cognitive Outcomes |
| الوصف: | CNS tumor patients are highly symptomatic causing interference with activity and worse quality of life. Social distancing due to the COVID-19 pandemic increased demands on the patient, caregivers, clinicians, and the health care system. The NCI’s Neuro-Oncology Branch Natural History Study (NHS) systematically collected patient-reported outcomes (PROs) provide insight into how these challenges influenced symptom burden and interference during the COVID year. METHODS: Patient and disease characteristic as well as patient-reported symptoms and interference (MDASI-BT/-SP) and general health status (EQ-5D-3L) from 3/2020-2/2021) were compared to NHS normative sample collected prior to 3/2020. RESULTS: The sample (n = 178) was primarily White (82%), male (55%), median age of 45 (range 18 – 79) and KPS ³ 90 (51%). The majority had high-grade (70%) brain (83%) tumors (BT) with ≥ 1 prior recurrence (60%) and 25% were on active treatment. Clinical visits were primarily conducted via telehealth (64%) and 20% of all patients were diagnosed with progression at the time of assessment. Most commonly reported moderate-severe symptoms among BT patients were fatigue (30%), difficulty remembering (28%), feeling drowsy (22%). Among spinal cord tumor patients, fatigue (39%), pain (35%) and numbness/tingling in arms/legs/trunk (35%) were most frequently reported. These symptoms were reported in similar frequencies by the normative sample. Nearly half of the COVID year sample (48%) reported moderate-severe activity-related interference. Reported problems with mobility (38%), self-care (19%), pain/discomfort (40%), and usual activities (50%) were similar in both groups except for increased mood disturbance (53%) was reported during the COVID year. CONCLUSION: These findings support CNS tumor patients remained highly symptomatic with significant impact on health-related quality of life during the COVID year. Clinicians should develop timely individual care plans to help BT patients navigate their disease course. Evaluation of risk associated with more severe symptoms and functional limitations are ongoing. |
| اللغة: | English |
| تدمد: | 1523-5866 1522-8517 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b6abea66449eda8e7dad7451d799e3 http://europepmc.org/articles/PMC8598790 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f4b6abea66449eda8e7dad7451d799e3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15235866 15228517 |
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