Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors
| العنوان: | Supramolecular azasugar clusters based on an amphiphilic fatty-acid-deoxynojirimycin derivative as multivalent glycosidase inhibitors |
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| المؤلفون: | Ya-Tong Peng, Yi-Xuan Liu, Hong-Xin Zhang, Jian-Xing Yang, Xiao-Liu Li, Min Li, Ke-Rang Wang |
| المصدر: | Journal of Materials Chemistry B. 7:1379-1383 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Blood Glucose, 1-Deoxynojirimycin, Cell Survival, Stereochemistry, Biomedical Engineering, Supramolecular chemistry, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Mice, chemistry.chemical_compound, alpha-Mannosidase, Amphiphile, medicine, Animals, Hypoglycemic Agents, General Materials Science, Glycoside hydrolase, Enzyme Inhibitors, Maltose, chemistry.chemical_classification, Glucosamine, Miglitol, Fatty Acids, Fatty acid, Glycosidase inhibitor, General Chemistry, General Medicine, Glucose Tolerance Test, Hydrogen-Ion Concentration, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, 0210 nano-technology, Derivative (chemistry), medicine.drug |
| الوصف: | A novel supramolecular multivalent glycosidase inhibitor was constructed based on the amphiphilic deoxynojirimycin derivative FA-DNJ. FA-DNJ self-assembled into spherical assemblies with the diameters between 103 nm and 137 nm under different pH values (pH 2-7) and showed a potent glycosidase effect against α-mannosidase with a Ki value of 0.11 μM, an effect that increased approximately 330-fold compared with that of miglitol. In addition, FA-DNJ exhibited a hypoglycaemic effect in mice. |
| تدمد: | 2050-7518 2050-750X |
| DOI: | 10.1039/c8tb03249a |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b0b65d9a7796378e8ad1d966a0f0e0 https://doi.org/10.1039/c8tb03249a |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f4b0b65d9a7796378e8ad1d966a0f0e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20507518 2050750X |
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| DOI: | 10.1039/c8tb03249a |