Genetic alteration of the hepatitis C virus hypervariable region obtained from an asymptomatic carrier
| العنوان: | Genetic alteration of the hepatitis C virus hypervariable region obtained from an asymptomatic carrier |
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| المؤلفون: | Takahide Nakazawa, Yuko Ootsuyama, Akitaka Shibuya, Takahiro Fujioka, Kunitada Shimotohno, Nobuyuki Kato, Hitomi Sekiya |
| المصدر: | International Journal of Cancer. 56:204-207 |
| بيانات النشر: | Wiley, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, viruses, Hepatitis C virus, Molecular Sequence Data, Immunoglobulin Variable Region, Genome, Viral, Hepacivirus, Biology, medicine.disease_cause, Polymerase Chain Reaction, Asymptomatic, Virus, Flaviviridae, Viral Envelope Proteins, medicine, Humans, Amino Acid Sequence, DNA Primers, Mutation, Base Sequence, virus diseases, biology.organism_classification, Hepatitis C, Virology, digestive system diseases, Hypervariable region, Oncology, DNA, Viral, Immunology, Viral disease, medicine.symptom, Asymptomatic carrier |
| الوصف: | Hepatitis C virus (HCV) genome shows extensive sequence diversity at 2 hypervariable regions (HVR1 and HVR2) of the putative envelope glycoprotein (gp70). We recently reported that the amino-acid sequence of HVR1, but not of HVR2, underwent a striking mutation or mutated sequentially over a period of several months in patients with chronic hepatitis (CH). Here, we examined whether these genetic alterations in HVR1 occurred in an asymptomatic HCV carrier. The level of HCV RNA in serum was almost the same throughout the 4 time points sampled over 16 months. However, we found that the amino-acid sequence of the HCV HVR1 from this asymptomatic carrier altered with time, as seen in patients with CH. Alterations of amino acids in the HVR1 were correlated with persistent HCV infection rather than with clinical symptoms. Sequence heterogeneity of HVR1 was not correlated with alanine aminotransferase (ALT) values or liver histological findings. The necessity of clinical follow-up of HCV asymptomatic carriers is discussed. |
| تدمد: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910560210 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4659cd8161b0805f099300bd6e4e94b https://doi.org/10.1002/ijc.2910560210 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f4659cd8161b0805f099300bd6e4e94b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970215 00207136 |
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| DOI: | 10.1002/ijc.2910560210 |