Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain
| العنوان: | Cross-region reduction in 5-hydroxymethylcytosine in Alzheimer's disease brain |
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| المؤلفون: | Condliffe, D, Wong, A, Troakes, C, Proitsi, P, Patel, Y, Chouliaras, L, Fernandes, C, Cooper, J, Lovestone, S, Schalkwyk, L, Mill, J, Lunnon, K |
| المساهمون: | MUMC+: DA BV AIOS Radiologie (9), Promovendi MHN, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie |
| المصدر: | Neurobiology of Aging, 35(8), 1850-1854. Elsevier Science |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Aging, Central nervous system, Fluorescent Antibody Technique, 5-caC, Biology, Methylation, Article, Epigenesis, Genetic, chemistry.chemical_compound, Cytosine, 5-fC, 5-carboxylcytosine, Alzheimer Disease, medicine, Humans, Epigenetics, 5-hydroxymethylcytosine, Aged, 5-Hydroxymethylcytosine, Aged, 80 and over, DNA methylation, Ivermectin, General Neuroscience, Brain, Human brain, Alzheimer's disease, medicine.disease, Entorhinal cortex, 5-Methylcytosine, medicine.anatomical_structure, 5-hmC, 5-formylcytosine, chemistry, Female, Neurology (clinical), Geriatrics and Gerontology, Neuroscience, 5-mC, Developmental Biology |
| الوصف: | Epigenetic processes play a key role in the central nervous system and altered levels of 5-methylcytosine have been associated with a number of neurologic phenotypes, including Alzheimer's disease (AD). Recently, 3 additional cytosine modifications have been identified (5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine), which are thought to be intermediate steps in the demethylation of 5-methylcytosine to unmodified cytosine. Little is known about the frequency of these modifications in the human brain during health or disease. In this study, we used immunofluorescence to confirm the presence of each modification in human brain and investigate their cross-tissue abundance in AD patients and elderly control samples. We identify a significant AD-associated decrease in global 5-hydroxymethylcytosine in entorhinal cortex and cerebellum, and differences in 5-formylcytosine levels between brain regions. Our study further implicates a role for epigenetic alterations in AD. © 2014 Elsevier Inc. |
| تدمد: | 1558-1497 0197-4580 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42fcb308c6baef93ab279ea4dc27193 http://ora.ox.ac.uk/objects/uuid:52715e7d-6fa7-42ec-af40-c293b2efc7f9 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f42fcb308c6baef93ab279ea4dc27193 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15581497 01974580 |
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