Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System
| العنوان: | Innovation in Nucleotide-Binding Oligomerization-Like Receptor and Toll-Like Receptor Sensing Drives the Major Histocompatibility Complex-II Free Atlantic Cod Immune System |
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| المؤلفون: | Monica Hongrø Solbakken, Bernat Morro, Visila Moiche, Ole K. Tørresen, Sissel Jentoft, Kjetill S. Jakobsen, Xing-Kun Jin, Simon MacKenzie |
| المصدر: | Frontiers in Immunology, Vol 11 (2020) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Immunology, NLR Proteins, macrophage, Major histocompatibility complex, immune response, MHC class II antigen, Major Histocompatibility Complex, Toll-like receptor (TLR), 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunology and Allergy, Animals, Humans, Scavenger receptor, Receptor, MAMP, Cells, Cultured, Original Research, Toll-like receptor, biology, Nucleotides, Macrophages, Toll-Like Receptors, NF-kappa B, cod, Cell biology, nucleotide-binding oligomerization-like receptor (NLR), 030104 developmental biology, Gadus morhua, Immune System, Interferon Regulatory Factors, biology.protein, lcsh:RC581-607, 030215 immunology, Interferon regulatory factors, Signal Transduction |
| الوصف: | The absence of MHC class II antigen presentation and multiple pathogen recognition receptors in the Atlantic cod has not impaired its immune response however how underlying mechanisms have adapted remains largely unknown. In this study,ex vivocod macrophages were challenged with various bacterial and viral microbe-associated molecular patterns (MAMP) to identify major response pathways. Cytosolic MAMP-PRR pathways based upon the NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs) were identified as the critical response pathways. Our analyses suggest that internalization of exogenous ligands through scavenger receptors drives both pathways activating transcription factors like NF-kB (Nuclear factor-kappa B) and interferon regulatory factors (IRFs). Further, ligand-dependent differential expression of a unique TLR25 isoform and multiple NLR paralogues suggests (sub)neofunctionalization toward specific immune defensive strategies. Our results further demonstrate that the unique immune system of the Atlantic cod provides an unprecedented opportunity to explore the evolutionary history of PRR-based signaling in vertebrate immunity. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| DOI: | 10.3389/fimmu.2020.609456/full |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3fcc8cdd137606349ef9540565e305c https://www.frontiersin.org/articles/10.3389/fimmu.2020.609456/full |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f3fcc8cdd137606349ef9540565e305c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2020.609456/full |