Co-Activation of Glucocorticoid Receptor and Peroxisome Proliferator–Activated Receptor-γ in Murine Skin Prevents Worsening of Atopic March
| العنوان: | Co-Activation of Glucocorticoid Receptor and Peroxisome Proliferator–Activated Receptor-γ in Murine Skin Prevents Worsening of Atopic March |
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| المؤلفون: | Hamida Hammad, Viacheslav Mylka, Marnik Vuylsteke, Michael Devos, Bart N. Lambrecht, Lode De Cauwer, Sofie Desmet, Giel Tanghe, Jan Tavernier, Justine Van Moorleghem, Nadia Bougarne, Manon Vanheerswynghels, Karolien De Bosscher, Jonathan Thommis, Astrid Luypaert, Julie Deckers |
| المصدر: | JOURNAL OF INVESTIGATIVE DERMATOLOGY Journal of Investigative Dermatology |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Peroxisome proliferator-activated receptor, Inflammation, KAPPA-B, Dermatology, DENDRITIC CELLS, Biochemistry, Allergic sensitization, 03 medical and health sciences, Glucocorticoid receptor, PPAR-ALPHA, Medicine and Health Sciences, HOUSE-DUST MITE, medicine, Molecular Biology, chemistry.chemical_classification, House dust mite, biology, business.industry, Biology and Life Sciences, ALLERGIC SENSITIZATION, GM-CSF, Cell Biology, Atopic dermatitis, TRANSACTIVATION, medicine.disease, biology.organism_classification, respiratory tract diseases, 3. Good health, DERMATITIS, 030104 developmental biology, chemistry, Nuclear receptor, MOUSE BONE-MARROW, Immunology, AGGRAVATES EXPERIMENTAL ASTHMA, medicine.symptom, business, Glucocorticoid, medicine.drug |
| الوصف: | Children with atopic dermatitis show an increased risk to develop asthma later in life, a phenomenon referred to as "atopic march," which emphasizes the need for secondary prevention therapies. This study aimed to investigate whether relief of skin inflammation by glucocorticoids and peroxisome proliferator-activated receptor agonists might influence the subsequent development of asthma in a murine model for the atopic march in which mice were repeatedly exposed to house dust mite via the skin, followed by exposure to house dust mite in lungs. To abrogate atopic dermatitis, mice received topical treatment with glucocorticoid receptor/peroxisome proliferator-activated receptor-gamma agonists. Nuclear receptor ligand effects were assessed on primary keratinocytes and dendritic cells, as central players in skin inflammation. Prior house dust mite-induced skin inflammation aggravates allergic airway inflammation and induces a mixed T helper type 2/T helper type 17 response in the lungs. Cutaneous combined activation of glucocorticoid receptor/peroxisome proliferator-activated receptor-gamma reduced skin inflammation to a higher extent compared to single activation. Additive anti-inflammatory effects were more prominent in dendritic cells, as compared to keratinocytes. Alleviation of allergic skin inflammation by activation of glucocorticoid receptor/peroxisome proliferator-activated receptor-gamma appeared insufficient to avoid the allergic immune response in the lungs, but efficiently reduced asthma severity by counteracting the Th17 response. Glucocorticoid receptor/peroxisome proliferator-activated receptor-gamma co-activation represents a potent remedy against allergic skin inflammation and worsening of atopic march. |
| وصف الملف: | application/pdf |
| تدمد: | 0022-202X |
| DOI: | 10.1016/j.jid.2017.12.023 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b9e660ed126f0303ac27bdfa951299 https://doi.org/10.1016/j.jid.2017.12.023 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f3b9e660ed126f0303ac27bdfa951299 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0022202X |
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| DOI: | 10.1016/j.jid.2017.12.023 |