Five-Year Changes in Weight and Diabetes Status After Bariatric Surgery for Craniopharyngioma-Related Hypothalamic Obesity: a Case–Control Study
| العنوان: | Five-Year Changes in Weight and Diabetes Status After Bariatric Surgery for Craniopharyngioma-Related Hypothalamic Obesity: a Case–Control Study |
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| المؤلفون: | Pauline Faucher, Claire Carette, Anne-Sophie Jannot, Blandine Gatta-Cherifi, Alexis Van Straaten, Marie-Astrid Piquet, Gerald Raverot, Maud Alligier, Thibault Batisse, Olivier Ziegler, Delphine Drui, Marion Bretault, Nicolas Farigon, Karem Slim, Laurent Genser, Tigran Poghosyan, Karina Vychnevskaia, Claire Blanchard, Maud Robert, Caroline Gronnier, Christine Poitou, Sébastien Czernichow |
| المصدر: | Obesity Surgery. 32:2321-2331 |
| بيانات النشر: | Springer Science and Business Media LLC, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Gastric Bypass, Bariatric Surgery, Obesity, Morbid, Craniopharyngioma, Diabetes Mellitus, Type 2, Gastrectomy, Case-Control Studies, Weight Loss, Humans, Pituitary Neoplasms, Surgery, Obesity, Retrospective Studies |
| الوصف: | Craniopharyngiomas are tumors located in the hypothalamic region which leads to obesity in about 50% of cases. Long-term efficacy and safety of bariatric surgery are lacking in this peculiar population. The aim of this study is to determine the 5-year weight loss and resolution of type 2 diabetes (T2D) after bariatric surgery in patients operated on craniopharyngioma who had developed hypothalamic obesity.This is a multicenter french retrospective case-control study. Subjects with craniopharyngioma (n = 23) who underwent sleeve gastrectomy (SG) (n = 9) or Roux-en-Y gastric bypass (RYGB) (n = 14) (median age 35 years [25;43] and BMI 44.2 kg/mTWL% after 1 and 5 years was lower in the craniopharyngioma group than in the control group: 23.1 [15.4; 31.1] (23/23) vs 31.4 [23.9; 35.3] at 1 year (p = 0.008) (46/46) and 17.8 [7.1; 21.9] (23/23) vs 26.2 [18.9; 33.9] at 5 years (p = 0.003) (46/46). After RYGB, TWL% was lower in the craniopharyngioma group compared to the control group (p 0.001) and comparable after SG both at 1 and 5 years. No difference between the two groups was observed in T2D remission rate and in early and late adverse events. No hormonal deficiency-related acute disease was reported.Bariatric surgery induced a significant weight loss in the craniopharyngioma group at 1 and 5 years, but less than in common obesity. SG may be more effective than RYGB but this remains to be demonstrated in a larger cohort. |
| تدمد: | 1708-0428 0960-8923 |
| DOI: | 10.1007/s11695-022-06079-9 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f341ae9daad1d9ce1979db2515916df0 https://doi.org/10.1007/s11695-022-06079-9 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f341ae9daad1d9ce1979db2515916df0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17080428 09608923 |
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| DOI: | 10.1007/s11695-022-06079-9 |