A prospective study of dietary flavonoid intake and risk of glioma in US men and women
| العنوان: | A prospective study of dietary flavonoid intake and risk of glioma in US men and women |
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| المؤلفون: | Meir J. Stampfer, Eric B. Rimm, Alaina M. Bever, Aedin Cassidy, David J. Cote |
| المصدر: | Am J Clin Nutr Bever, A M, Cassidy, A, Rimm, E B, Stampfer, M J & Cote, D J 2021, ' A prospective study of dietary flavonoid intake and risk of glioma in US men and women ', American Journal of Clinical Nutrition . https://doi.org/10.1093/ajcn/nqab178 |
| بيانات النشر: | Oxford University Press, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Flavonoid, Medicine (miscellaneous), Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Male health, Risk Factors, Internal medicine, Glioma, Epidemiology, medicine, Humans, Prospective Studies, Prospective cohort study, chemistry.chemical_classification, Flavonoids, Nutrition and Dietetics, business.industry, Medical record, food and beverages, Middle Aged, medicine.disease, Diet, Original Research Communications, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Nurses' Health Study, Female, Self Report, business, Food Analysis, Dietary Flavonoid |
| الوصف: | Background:Flavonoids are a diverse group of plant constituents with demonstrated neuroprotective and anti-tumor effects. Flavonoid intake may decrease the risk of glioma, but the possibility of an association has not yet been investigated in humans.Objectives:We evaluated the association between dietary flavonoid consumption and the risk of glioma.Methods:We followed participants in the female Nurses’ Health Study (1984–2014; n = 81,688) and Nurses’ Health Study II (1991–2017; n = 95,228) and the male Health Professionals Follow-Up Study (1986–2014; n = 49,885). We used multivariable-adjusted Cox proportional hazards regression models to evaluate the associations between average long-term (up to 30 years) or recent (up to 12 years) dietary flavonoid intake (total flavonoids and each of 6 subclasses) and risks of incident glioma. Flavonoid intake was derived from validated quadrennial FFQs. Incident glioma was self-reported and confirmed by a medical record review or was determined by a medical record review after death.Results:We documented 536 incident cases of glioma across 5,936,386 person-years of follow-up. Long-term total flavonoid, flavan-3-ol, and polymeric flavonoid (polymer) intakes were associated with decreased glioma risks in pooled analyses comparing the highest to lowest quintiles of consumption [HR, 0.79 (95% CI, 0.59–1.05; P-trend = 0.04) for total flavonoids; 0.76 (95% CI, 0.57–1.01; P-trend = 0.04) for flavan-3-ols; and 0.82 (95% CI, 0.61–1.09; P-trend = 0.05) for polymers]. Associations with recent intake were weaker. There were no associations with other flavonoid subclasses. After additional adjustment for tea consumption, there were no associations between flavan-3-ol or polymer consumption and glioma.Conclusions:Increased dietary intakes of flavan-3-ol and polymeric flavonoids, especially those predominant in tea, were associated with decreased glioma risks in a prospective cohort of men and women. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/ajcn/nqab178 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ea4e42e34019d34fc146883e11f5eb https://europepmc.org/articles/PMC8488865/ |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f2ea4e42e34019d34fc146883e11f5eb |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.1093/ajcn/nqab178 |
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