Baseline 10-Year Cardiovascular Risk Scores Predict Cognitive Function in Older Persons, and Particularly Women, Living With Human Immunodeficiency Virus Infection
| العنوان: | Baseline 10-Year Cardiovascular Risk Scores Predict Cognitive Function in Older Persons, and Particularly Women, Living With Human Immunodeficiency Virus Infection |
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| المؤلفون: | Virginia A. Triant, Asya Lyass, Ralph B. D'Agostino, Taylor F. Mahoney, Joseph M. Massaro, Felicia C. Chow, Babafemi Taiwo, Kunling Wu, Baiba Berzins, Ronald J. Ellis, Kevin Robertson, Katherine Tassiopoulos |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 71, iss 12 Clin Infect Dis |
| بيانات النشر: | eScholarship, University of California, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Aging, Human immunodeficiency virus (HIV), HIV Infections, Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, Cardiovascular, Medical and Health Sciences, risk prediction, 0302 clinical medicine, Framingham Heart Study, Cognition, Risk Factors, 80 and over, Cognitive impairment, Aged, 80 and over, Framingham Risk Score, Middle Aged, Biological Sciences, CVD, Infectious Diseases, Heart Disease, Cardiovascular Diseases, Cohort, Female, Microbiology (medical), cardiovascular risk, medicine.medical_specialty, Cardiovascular risk factors, Risk Assessment, Microbiology, 03 medical and health sciences, Clinical Research, Internal medicine, Behavioral and Social Science, medicine, Humans, cognitive function, Aged, business.industry, Prevention, HIV, HIV infection, Major Articles and Commentaries, Good Health and Well Being, Heart Disease Risk Factors, business, 030217 neurology & neurosurgery |
| الوصف: | BackgroundCardiovascular disease (CVD) and associated comorbidities increase the risk of cognitive impairment in persons living with human immunodeficiency virus (PLWH). Given the potential composite effect of multiple cardiovascular risk factors on cognition, we examined the ability of the Atherosclerotic Cardiovascular Disease (ASCVD) risk score and the Framingham Heart Study Global CVD risk score (FRS) to predict future cognitive function in older PLWH.MethodsWe constructed linear regression models evaluating the association between baseline 10-year cardiovascular risk scores and cognitive function (measured by a summary z-score, the NPZ-4) at a year 4 follow-up visit.ResultsAmong 988 participants (mean age, 52 years; 20% women), mean 10-year ASCVD risk score at entry into the cohort was 6.8% (standard deviation [SD], 7.1%) and FRS was 13.1% (SD, 10.7%). In models adjusted only for cognitive function at entry, the ASCVD risk score significantly predicted year 4 NPZ-4 in the entire cohort and after stratification by sex (for every 1% higher ASCVD risk, year 4 NPZ-4 was lower by 0.84 [SD, 0.28] overall, P = .003; lower by 2.17 [SD, 0.67] in women, P = .001; lower by 0.78 [SD, 0.32] in men, P = .016). A similar relationship was observed between FRS and year 4 NPZ-4. In multivariable models, higher 10-year ASCVD risk and FRS predicted lower NPZ-4 in women.ConclusionsBaseline 10-year ASCVD risk and FRS predicted future cognitive function in older PLWH with well-controlled infection. Cardiovascular risk scores may help to identify PLWH, especially women, who are at risk for worse cognition over time. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b44806eeb943f1035cb4618d6e89aa https://escholarship.org/uc/item/5qb2g0b6 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f2b44806eeb943f1035cb4618d6e89aa |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |