Clinical and histologic presentation of pediatric reactive granulomatous dermatitis
| العنوان: | Clinical and histologic presentation of pediatric reactive granulomatous dermatitis |
|---|---|
| المؤلفون: | Cordellia Nguyen, Logan C. DeBord, Olushola L. Akinshemoyin Vaughn, Marcia Hogeling, Olayemi Sokumbi, James W. Verbsky, Raegan D. Hunt, Dawn H. Siegel, Yvonne E. Chiu, Lisa M. Arkin |
| المصدر: | Pediatric Dermatology. 37:498-503 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Dermatitis, Dermatology, Disease, Autoimmune Diseases, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Child, Histiocyte, Retrospective Studies, Granuloma, business.industry, Mucin, Clinical course, Histology, Erythema, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, Female, Presentation (obstetrics), Granulomatous Dermatitis, business, Pediatric population |
| الوصف: | Objective To characterize the clinical and histologic presentation of reactive granulomatous dermatitis (RGD) in the pediatric population. Methods In this multicenter retrospective chart review, 7 pediatric patients with biopsy-proven RGD were identified. Photographs, histology reports, and clinical course were reviewed to discover patterns in demographics, comorbid conditions, autoimmune sequelae, drug exposures, infections, morphology, and histologic features. Results Overall, 7 patients were included and analyzed. Most were female and Hispanic. All presented with a similar dermatologic phenotype previously described in the adult literature including macular erythema and annular, pink to violaceous, edematous papules and plaques, often involving proximal extremities and extensor joints. All biopsies demonstrated variable collagen alteration and a perivascular interstitial infiltrate of histiocytes with or without mucin. Neutrophils or karyorrhexic debris were present in 4/7 of the biopsies, and eosinophils were occasionally seen (2/7 cases). In all cases, RGD was associated with active SLE or led to a new diagnosis, and initiation of systemic treatment improved cutaneous disease. Conclusions Pediatric RGD was more common in female patients and ethnic minorities, and strongly associated with SLE. Clinical and histologic presentations were consistent across all cases with only minor variations, suggesting that recognition and confirmation might be expedited by familiarity with these dominant patterns. Diagnosis of RGD in pediatric patients should prompt screening for SLE. |
| تدمد: | 1525-1470 0736-8046 |
| DOI: | 10.1111/pde.14137 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a4a105ec53affe0826b3bf0ac113f5 https://doi.org/10.1111/pde.14137 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f2a4a105ec53affe0826b3bf0ac113f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251470 07368046 |
|---|---|
| DOI: | 10.1111/pde.14137 |