Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates
| العنوان: | Proteomic profiling of human cancer pseudopodia for the identification of anti-metastatic drug candidates |
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| المؤلفون: | Neha Goswami, Sunkyu Choi, Rasha Al Mismar, Aditya M. Bhagwat, Hisham Ben Hamidane, Lu Sun, Johannes Graumann |
| المصدر: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Proteomics, lcsh:Medicine, Antineoplastic Agents, Biology, Article, Metastasis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Rocaglamide, Cell Movement, Cell Line, Tumor, Prohibitins, medicine, Humans, Pseudopodia, Neoplasm Metastasis, lcsh:Science, Benzofurans, Gene knockdown, Multidisciplinary, Proteomic Profiling, lcsh:R, Cancer, medicine.disease, Repressor Proteins, 030104 developmental biology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Cancer cell, Cancer research, lcsh:Q |
| الوصف: | Cancer metastasis causes approximately 90% of all cancer-related death and independent of the advancement of cancer therapy, a majority of late stage patients suffers from metastatic cancer. Metastasis implies cancer cell migration and invasion throughout the body. Migration requires the formation of pseudopodia in the direction of movement, but a detailed understanding of this process and accordingly strategies of prevention remain elusive. Here, we use quantitative proteomic profiling of human cancer pseudopodia to examine this mechanisms essential to metastasis formation, and identify potential candidates for pharmacological interference with the process. We demonstrate that Prohibitins (PHBs) are significantly enriched in the pseudopodia fraction derived from cancer cells, and knockdown of PHBs, as well as their chemical inhibition through Rocaglamide (Roc-A), efficiently reduces cancer cell migration. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2591d5c2417a3b8bc2e9f7b2f87409c https://pubmed.ncbi.nlm.nih.gov/29643415 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f2591d5c2417a3b8bc2e9f7b2f87409c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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