The Incidence of Metabolic Syndrome in Obese Czech Children: the Importance of Early Detection of Insulin Resistance Using Homeostatic Indexes HOMA-IR and QUICKI
| العنوان: | The Incidence of Metabolic Syndrome in Obese Czech Children: the Importance of Early Detection of Insulin Resistance Using Homeostatic Indexes HOMA-IR and QUICKI |
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| المؤلفون: | Z. Marinov, L. Radova, D. Horakova, Dalibor Pastucha, J. Malinčíková, Marcela Bezdickova, Martin Dobiáš, M. Kocvrlich, Slavomír Horák, Radka Filipčíková |
| المصدر: | Scopus-Elsevier |
| بيانات النشر: | Institute of Physiology of the Czech Academy of Sciences, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, Pediatrics, Adolescent, Physiology, Early detection, Comorbidity, Sensitivity and Specificity, Insulin resistance, Risk Factors, Internal medicine, medicine, Humans, Insulin, Obesity, Child, Czech Republic, Metabolic Syndrome, business.industry, Incidence, Incidence (epidemiology), Reproducibility of Results, General Medicine, Anthropometry, medicine.disease, Causality, Early Diagnosis, Endocrinology, Population Surveillance, Female, Insulin Resistance, Metabolic syndrome, business, Homeostasis |
| الوصف: | Common alimentary obesity frequently occurs on a polygenic basis as a typical lifestyle disorder in the developed countries. It is associated with characteristic complex metabolic changes, which are the cornerstones for future metabolic syndrome development. The aims of our study were 1) to determine the incidence of metabolic syndrome (based on the diagnostic criteria defined by the International Diabetes Federation for children and adolescents) in Czech obese children, 2) to evaluate the incidence of insulin resistance according to HOMA-IR and QUICKI homeostatic indexes in obese children with and without metabolic syndrome, and 3) to consider the diagnostic value of these indexes for the early detection of metabolic syndrome in obese children. We therefore performed anthropometric and laboratory examinations to determine the incidence of metabolic syndrome and insulin resistance in the group of 274 children with obesity (128 boys and 146 girls) aged 9-17 years. Metabolic syndrome was found in 102 subjects (37 %). On the other hand, the presence of insulin resistance according to QUICKI 3.16 in 53 % of obese subjects. This HOMA-IR limit was exceeded by 70 % children in the MS(+) group, but only by 43 % children in the MS(–) group (p |
| تدمد: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.932438 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24e474a4254e65d7f532dcdd3946c54 https://doi.org/10.33549/physiolres.932438 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f24e474a4254e65d7f532dcdd3946c54 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18029973 08628408 |
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| DOI: | 10.33549/physiolres.932438 |