Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction
| العنوان: | Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction |
|---|---|
| المؤلفون: | Gary Williamson, Asimina Kerimi |
| المصدر: | Biochemical Pharmacology |
| بيانات النشر: | Elsevier Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, In silico, TMPRSS2, transmembrane protease, serine 2, Pneumonia, Viral, Drug Evaluation, Preclinical, Absorption (skin), Pharmacology, Peptidyl-Dipeptidase A, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Betacoronavirus, 0302 clinical medicine, Biotransformation, Renin–angiotensin system, ACE2, angiotensin converting enzyme-2, Humans, SARS, severe acute respiratory syndrome, Pandemics, ComputingMethodologies_COMPUTERGRAPHICS, Biological Products, Clinical Trials as Topic, Molecular Structure, Chemistry, SARS-CoV-2, COVID-19, ADAM-17, ADAM metallopeptidase domain 17, Epithelial Cells, Metabolism, Virus Internalization, Clinical trial, 030104 developmental biology, 030220 oncology & carcinogenesis, Angiotensin-converting enzyme 2, Host-Pathogen Interactions, Spike Glycoprotein, Coronavirus, Quercetin, Angiotensin-Converting Enzyme 2, Coronavirus Infections, Protein Binding |
| الوصف: | Graphical abstract Commonly used drugs for treating many conditions are either natural products or derivatives. In silico modelling has identified several natural products including quercetin as potential highly effective disruptors of the initial infection process involving binding to the interface between the SARS-CoV-2 (Covid-19) Viral Spike Protein and the epithelial cell Angiotensin Converting Enzyme-2 (ACE2) protein. Here we argue that the oral route of administration of quercetin is unlikely to be effective in clinical trials owing to biotransformation during digestion, absorption and metabolism, but suggest that agents could be administered directly by alternative routes such as a nasal or throat spray. |
| اللغة: | English |
| تدمد: | 1873-2968 0006-2952 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f24c94ffd8aac41de68e663761f03bdc http://europepmc.org/articles/PMC7316054 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f24c94ffd8aac41de68e663761f03bdc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18732968 00062952 |
|---|