The paradoxical role of radiation‐induced cGAS–STING signalling network in tumour immunity
| العنوان: | The paradoxical role of radiation‐induced |
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| المؤلفون: | Xiaoyi Zhang, Han Zhang, Jiajia Zhang, Mengdie Yang, Mengqin Zhu, Yuzhen Yin, Xin Fan, Fei Yu |
| المصدر: | Immunology. 168:375-388 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Immunology, Immunology and Allergy |
| الوصف: | The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is an essential component of the innate immune system and is central to the identification of abnormal DNA leakage caused by ionising radiation (IR) damage. Cell-intrinsic cGAS-STING initiation has been revealed to have tremendous potential for facilitating interferon synthesis and T-cell priming. Targeting the cGAS-STING axis has been proposed as a strategy to improve radiosensitivity or enhance immunosurveillance. However, due to the complex biology of the irradiated tumour microenvironment and the extensive involvement of the cGAS-STING pathway in various physiological and pathological processes, many defects in this strategy limit the therapeutic effect. Here, we outline the molecular mechanisms by which IR activates the cGAS-STING pathway and analyse the dichotomous roles of the cGAS-STING pathway in modulating cancer immunity after radiotherapy (RT). Then, based on the crosstalk between the cGAS-STING pathway and other signalling events induced by IR, such as necroptosis, autophagy and other cellular effects, we discuss the immunomodulatory actions of the broad cGAS-STING signalling network in RT and their potential therapeutic applications. Finally, recent advances in combination therapeutic strategies targeting cGAS-STING in RT are explored. |
| تدمد: | 1365-2567 0019-2805 |
| DOI: | 10.1111/imm.13592 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e9f132f4f71050110ccdbc0f065852 https://doi.org/10.1111/imm.13592 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....f1e9f132f4f71050110ccdbc0f065852 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652567 00192805 |
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| DOI: | 10.1111/imm.13592 |