Race affects outcome among infants with intestinal failure

التفاصيل البيبلوغرافية
العنوان: Race affects outcome among infants with intestinal failure
المؤلفون: Robert H. Squires, Christopher Duggan, Ruosha Li, Steven H. Belle, Paul W. Wales, Jane Balint, Jason S. Soden, Simon Horslen
المصدر: Journal of pediatric gastroenterology and nutrition, vol 59, iss 4
بيانات النشر: eScholarship, University of California, 2014.
سنة النشر: 2014
مصطلحات موضوعية: Male, Pediatrics, medicine.medical_specialty, Medical and Health Sciences, Article, Oral and gastrointestinal, Cohort Studies, Clinical Research, Medicine, Humans, Cumulative incidence, Intensive care medicine, Retrospective Studies, Pediatric, Transplantation, Pediatric Intestinal Failure Consortium, Continental Population Groups, Gastroenterology & Hepatology, business.industry, Medical record, Racial Groups, Gastroenterology, Infant, Evaluation of treatments and therapeutic interventions, Retrospective cohort study, Organ Transplantation, Intestines, Low birth weight, Intestinal Diseases, Parenteral nutrition, 6.1 Pharmaceuticals, Pediatrics, Perinatology and Child Health, Cohort, Female, medicine.symptom, business, Digestive Diseases, Cohort study
الوصف: OBJECTIVE Intestinal failure (IF) is a rare, devastating condition associated with significant morbidity and mortality. We sought to determine whether ethnic and racial differences were associated with patient survival and likelihood of receiving an intestinal transplant in a contemporary cohort of children with IF. METHODS This was an analysis of a multicenter cohort study with data collected from chart review conducted by the Pediatric Intestinal Failure Consortium. Entry criteria included infants ≤ 12 months receiving parenteral nutrition (PN) for ≥ 60 continuous days and studied for at least 2 years. Outcomes included death and intestinal transplantation (ITx). Race and ethnicity were recorded as they were in the medical record. For purposes of statistical comparisons and regression modeling, categories of race were consolidated into "white" and "nonwhite" children. RESULTS Of 272 subjects enrolled, 204 white and 46 nonwhite children were available for analysis. The 48-month cumulative incidence probability of death without ITx was 0.40 for nonwhite and 0.16 for white children (P < 0.001); the cumulative incidence probability of ITx was 0.07 for nonwhite versus 0.31 for white children (P = 0.003). The associations between race and outcomes remained after accounting for low birth weight, diagnosis, and being seen at a transplant center. CONCLUSIONS Race is associated with death and receiving an ITx in a large cohort of children with IF. This study highlights the need to investigate reasons for this apparent racial disparity in outcome among children with IF.
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cbe58f604dc7cc3afcb12662ee3007
https://escholarship.org/uc/item/5300p5ch
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....f1cbe58f604dc7cc3afcb12662ee3007
قاعدة البيانات: OpenAIRE